PD-L1 as a Novel Mediator of Lung Fibroblast to Myofibroblast Transition

doi:10.33696/immunology.4.142

. 2022;4(4):141-144.

doi: 10.33696/immunology.4.142.

PD-L1 as a Novel Mediator of Lung Fibroblast to Myofibroblast Transition

Xia Guo¹, Guoqing Qian¹

Affiliations

PMID: 36437908
PMCID: PMC9696593
DOI: 10.33696/immunology.4.142

PD-L1 as a Novel Mediator of Lung Fibroblast to Myofibroblast Transition

Xia Guo et al. J Cell Immunol. 2022.

. 2022;4(4):141-144.

doi: 10.33696/immunology.4.142.

Authors

Xia Guo¹, Guoqing Qian¹

Affiliation

¹ Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, USA.

PMID: 36437908
PMCID: PMC9696593
DOI: 10.33696/immunology.4.142

No abstract available

Keywords: Fibroblast to myofibroblast transition; Lung; PD-L1; Pulmonary fibrosis; Transforming growth factor β.

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Conflict of interest statement

Conflicts of Interest The authors have no conflict of interest to declare.

Figures

**Figure 1:**
A diagram of the mechanisms by which PD-L1 mediates fibroblast to myofibroblast transition (FMT).

See this image and copyright information in PMC

Cited by

Evaluation of PD-1 T lymphocytes in bronchoalveolar lavage in lung cancer compared to benign lung diseases.
Hammer B, Bal C, Gysan M, Zehetmayer S, Geleff S, Zech A, Kramer M, Ayazseven S, Idzko M, Mosleh B, Hoda MA, Gompelmann D. Hammer B, et al. Clin Exp Med. 2023 Dec;23(8):5177-5182. doi: 10.1007/s10238-023-01146-6. Epub 2023 Aug 3. Clin Exp Med. 2023. PMID: 37535195 Free PMC article.

References

1. Olson AL, Gifford AH, Inase N, Fernandez Perez ER, Suda T. The epidemiology of idiopathic pulmonary fibrosis and interstitial lung diseases at risk of a progressive-fibrosing phenotype. Eur Respir Rev. 2018;27(150). - PMC - PubMed
1. Patsoukis N,Wang Q, Strauss L, Boussiotis VA. Revisiting the PD-1 pathway. Sci Adv. 2020;6(38):eabd2712. - PMC - PubMed
1. Han Y, Liu D, Li L. PD-1/PD-L1 pathway: current researches in cancer. Am J Cancer Res. 2020;10:727–42. - PMC - PubMed
1. Cui L, Chen SY, Lerbs T, Lee JW, Domizi P, Gordon S, et al. Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity. Nat Commun. 2020;11:2795. - PMC - PubMed
1. Kang JH, Jung MY, Choudhury M, Leof EB. Transforming growth factor beta induces fibroblasts to express and release the immunomodulatory protein PD-L1 into extracellular vesicles. FASEB J. 2020;34:2213–26. - PubMed

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[1] Olson AL, Gifford AH, Inase N, Fernandez Perez ER, Suda T. The epidemiology of idiopathic pulmonary fibrosis and interstitial lung diseases at risk of a progressive-fibrosing phenotype. Eur Respir Rev. 2018;27(150). - PMC - PubMed

[2] Olson AL, Gifford AH, Inase N, Fernandez Perez ER, Suda T. The epidemiology of idiopathic pulmonary fibrosis and interstitial lung diseases at risk of a progressive-fibrosing phenotype. Eur Respir Rev. 2018;27(150). - PMC - PubMed

[3] Patsoukis N,Wang Q, Strauss L, Boussiotis VA. Revisiting the PD-1 pathway. Sci Adv. 2020;6(38):eabd2712. - PMC - PubMed

[4] Patsoukis N,Wang Q, Strauss L, Boussiotis VA. Revisiting the PD-1 pathway. Sci Adv. 2020;6(38):eabd2712. - PMC - PubMed

[5] Han Y, Liu D, Li L. PD-1/PD-L1 pathway: current researches in cancer. Am J Cancer Res. 2020;10:727–42. - PMC - PubMed

[6] Han Y, Liu D, Li L. PD-1/PD-L1 pathway: current researches in cancer. Am J Cancer Res. 2020;10:727–42. - PMC - PubMed

[7] Cui L, Chen SY, Lerbs T, Lee JW, Domizi P, Gordon S, et al. Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity. Nat Commun. 2020;11:2795. - PMC - PubMed

[8] Cui L, Chen SY, Lerbs T, Lee JW, Domizi P, Gordon S, et al. Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity. Nat Commun. 2020;11:2795. - PMC - PubMed

[9] Kang JH, Jung MY, Choudhury M, Leof EB. Transforming growth factor beta induces fibroblasts to express and release the immunomodulatory protein PD-L1 into extracellular vesicles. FASEB J. 2020;34:2213–26. - PubMed

[10] Kang JH, Jung MY, Choudhury M, Leof EB. Transforming growth factor beta induces fibroblasts to express and release the immunomodulatory protein PD-L1 into extracellular vesicles. FASEB J. 2020;34:2213–26. - PubMed

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PD-L1 as a Novel Mediator of Lung Fibroblast to Myofibroblast Transition

Affiliation

PD-L1 as a Novel Mediator of Lung Fibroblast to Myofibroblast Transition

Authors

Affiliation

Conflict of interest statement

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References

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Full Text Sources

Research Materials