Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Nov 16;11(22):3135.
doi: 10.3390/plants11223135.

Plant Pyranocoumarins: Description, Biosynthesis, Application

Affiliations
Review

Plant Pyranocoumarins: Description, Biosynthesis, Application

Maria T Khandy et al. Plants (Basel). .

Abstract

This overview article contains information about pyranocoumarins over the last 55 years. The article is based on the authors' phytochemical and physiological studies in vivo and in vitro as well as search and analysis of data in literature available on Google Scholar, Web of Science, PubMed, and ScienceDirect before January 2022. Pyranocoumarins are synthesized in plants of the Apiaceae, Rutaceae families, and one species in each of the Cornaceae, Calophyllaceae, and Fabaceae families can synthesize this class of compounds. The physiological role of these compounds in plants is not clear. It has been proven that these substances have a wide range of biological activities: anti-cancer, anti-spasmatic, and anticoagulant, and they also inhibit erythrocyte lysis and accumulation of triacylglycerides. The overview generalizes the modern understanding of the classification, structure, and biological activity of natural pyranocoumarins, and summarizes dispersed data into a unified scheme of biosynthesis. The review analyzes data on the localization and productivity of these substances in individual organs and the whole plant. It discusses a link between the unique structure of these substances and their biological activity, as well as new opportunities for pyranocoumarins in pharmacology. The article evaluates the potential of different plant species as producers of pyranocoumarins and considers the possibilities of cell cultures to obtain the end product.

Keywords: biosynthesis of pyranocoumarins; classification of pyranocoumarins; coumarins; functions of pyranocoumarins; pyranocoumarins; structure of pyranocoumarins.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript.

Figures

Figure 1
Figure 1
Natural groups of pyranocoumarins: (a) linear pyranocoumarin; (b) 5,6-angular pyranocoumarin; (c) 6,7-angular pyranocoumarin; (d) condensed pyranocoumarin.
Figure 2
Figure 2
Biosynthesis pathway of umbelliferone, a precursor of pyranocoumarins.
Figure 3
Figure 3
Biosynthesis of pyranocoumarins.
Figure 4
Figure 4
Distribution of linear and angular pyranocoumarins within the Umbelliferae and Rutaceae families. Mix-Ad and L pyranocoumarins; Ad-angular 7,8-pyranocoumarin; L-linear 6,7-pyranocoumarin.

Similar articles

Cited by

References

    1. Bynum H., Bynum W. Remarkable Plants That Shape Our World. University of Chicago Press; Chicago, IL, USA: 2014. p. 239.
    1. Veeresham C. Natural products derived from plants as a source of drugs. J. Adv. Pharm. Technol. Res. 2012;3:200–201. doi: 10.4103/2231-4040.104709. - DOI - PMC - PubMed
    1. Soriano-Castell D., Liang Z., Maher P., Currais A. The search for anti-oxytotic/ferroptotic compounds in the plant world. Br. J. Pharmacol. 2021;178:3611–3626. doi: 10.1111/bph.15517. - DOI - PMC - PubMed
    1. Ledford H. World’s largest plant survey reveals alarming extinction rate. Nature. 2019;570:148–149. doi: 10.1038/d41586-019-01810-6. - DOI - PubMed
    1. Zobel A.M., Brown S.A. Coumarins in the interections between the plant and its environment. Allelopath. J. 1995;2:9–20.

LinkOut - more resources