Plant Pyranocoumarins: Description, Biosynthesis, Application
- PMID: 36432864
- PMCID: PMC9693251
- DOI: 10.3390/plants11223135
Plant Pyranocoumarins: Description, Biosynthesis, Application
Abstract
This overview article contains information about pyranocoumarins over the last 55 years. The article is based on the authors' phytochemical and physiological studies in vivo and in vitro as well as search and analysis of data in literature available on Google Scholar, Web of Science, PubMed, and ScienceDirect before January 2022. Pyranocoumarins are synthesized in plants of the Apiaceae, Rutaceae families, and one species in each of the Cornaceae, Calophyllaceae, and Fabaceae families can synthesize this class of compounds. The physiological role of these compounds in plants is not clear. It has been proven that these substances have a wide range of biological activities: anti-cancer, anti-spasmatic, and anticoagulant, and they also inhibit erythrocyte lysis and accumulation of triacylglycerides. The overview generalizes the modern understanding of the classification, structure, and biological activity of natural pyranocoumarins, and summarizes dispersed data into a unified scheme of biosynthesis. The review analyzes data on the localization and productivity of these substances in individual organs and the whole plant. It discusses a link between the unique structure of these substances and their biological activity, as well as new opportunities for pyranocoumarins in pharmacology. The article evaluates the potential of different plant species as producers of pyranocoumarins and considers the possibilities of cell cultures to obtain the end product.
Keywords: biosynthesis of pyranocoumarins; classification of pyranocoumarins; coumarins; functions of pyranocoumarins; pyranocoumarins; structure of pyranocoumarins.
Conflict of interest statement
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript.
Figures
Similar articles
-
Progress in the Chemistry of Naturally Occurring Coumarins.Prog Chem Org Nat Prod. 2017;106:241-304. doi: 10.1007/978-3-319-59542-9_3. Prog Chem Org Nat Prod. 2017. PMID: 28762091 Review.
-
A Review on the Morphology, Cultivation, Identification, Phytochemistry, and Pharmacology of Kitagawia praeruptora (Dunn) Pimenov.Molecules. 2023 Dec 18;28(24):8153. doi: 10.3390/molecules28248153. Molecules. 2023. PMID: 38138641 Free PMC article. Review.
-
Multicomponent Synthesis Strategies, Catalytic Activities, and Potential Therapeutic Applications of Pyranocoumarins: A Comprehensive Review.Chem Biodivers. 2023 Oct;20(10):e202300836. doi: 10.1002/cbdv.202300836. Epub 2023 Oct 5. Chem Biodivers. 2023. PMID: 37702294 Review.
-
A Review on Anomalin: A Natural Bioactive Pyranocoumarin from the Past to the Future.Chem Biodivers. 2022 Sep;19(9):e202200167. doi: 10.1002/cbdv.202200167. Epub 2022 Aug 31. Chem Biodivers. 2022. PMID: 35544308 Review.
-
Pyranocoumarins from Zosima absinthifolia (Vent) Link roots.Bioorg Khim. 2013 Mar-Apr;39(2):244-6. doi: 10.1134/s106816201301010x. Bioorg Khim. 2013. PMID: 23964526
Cited by
-
Inhibitory Activity of Natural cis-Khellactone on Soluble Epoxide Hydrolase and Proinflammatory Cytokine Production in Lipopolysaccharides-Stimulated RAW264.7 Cells.Plants (Basel). 2023 Oct 23;12(20):3656. doi: 10.3390/plants12203656. Plants (Basel). 2023. PMID: 37896119 Free PMC article.
-
Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action.Int J Mol Sci. 2023 Feb 2;24(3):2839. doi: 10.3390/ijms24032839. Int J Mol Sci. 2023. PMID: 36769163 Free PMC article. Review.
-
Construction of 4-hydroxycoumarin derivatives with adjacent quaternary and tertiary stereocenters via ternary catalysis.Chem Sci. 2023 Oct 16;14(42):11850-11857. doi: 10.1039/d3sc03452f. eCollection 2023 Nov 1. Chem Sci. 2023. PMID: 37920338 Free PMC article.
-
Synthesis and Biological Properties of Pyranocoumarin Derivatives as Potent Anti-Inflammatory Agents.Int J Mol Sci. 2023 Jun 12;24(12):10026. doi: 10.3390/ijms241210026. Int J Mol Sci. 2023. PMID: 37373174 Free PMC article.
-
The Different Composition of Coumarins and Antibacterial Activity of Phlojodicarpus sibiricus and Phlojodicarpus villosus Root Extracts.Plants (Basel). 2024 Feb 22;13(5):601. doi: 10.3390/plants13050601. Plants (Basel). 2024. PMID: 38475448 Free PMC article.
References
-
- Bynum H., Bynum W. Remarkable Plants That Shape Our World. University of Chicago Press; Chicago, IL, USA: 2014. p. 239.
-
- Zobel A.M., Brown S.A. Coumarins in the interections between the plant and its environment. Allelopath. J. 1995;2:9–20.
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources