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Review
. 2022;46(1):267.
doi: 10.1186/s42269-022-00955-1. Epub 2022 Nov 17.

The role of miRNAs in viral myocarditis, and its possible implication in induction of mRNA-based COVID-19 vaccines-induced myocarditis

Antoine AbdelMassih  1   2 , Hala Agha  1 , Sonia El-Saiedi  1 , Amal El-Sisi  1 , Meryam El Shershaby  3 , Hanya Gaber  3 , Habiba-Allah Ismail  3 , Nadine El-Husseiny  4   5 , Abeer Reda Amin  3 , Aly ElBoraie  3 , Aya Ayad  3 , Esraa Menshawey  3 , Fady Sefein  3 , Ibrahim Ihab Osman  3 , Mai Moursi  3 , Maram Hanafy  3 , Mariam Sherif Abdelaziz  3 , Mariem Badr Arsanyous  3 , Mariam Khaled-Ibn-El-Walid  3 , Marwa Gamal Tawfik  3 , Menna Habib  3 , Mina Ehab Mansour  3 , Mirette Ashraf  3 , Mohamed Ayman Khattab  3 , Nada Alshehry  3 , Nada Hafez  3 , Naheel Essam ElDeeb  3 , Nirvana Ashraf  3 , Noha Khalil  3 , Noheir Ismail AbdElSalam  3 , Noura Shebl  3 , Nouran Gamal Ali Hafez  3 , Nourhan Hatem Youssef  3 , Odette Bahnan  3 , Passant Ismail  3 , Peter Kelada  3 , Rahma Menshawey  3 , Rana Saeed  3 , Reem Jalal Husseiny  3 , Reem Yasser  3 , Safa Sharaf  3 , Veronia Adel  3 , Youstina Naeem  3 , Youstina Nagy Farid Nicola  3 , Aya Kamel  3 , Rafeef Hozaien  3 , Raghda Fouda  6
Affiliations
Review

The role of miRNAs in viral myocarditis, and its possible implication in induction of mRNA-based COVID-19 vaccines-induced myocarditis

Antoine AbdelMassih et al. Bull Natl Res Cent. 2022.

Abstract

Background: Several reports of unheeded complications secondary to the current mass international rollout of SARS-COV-2 vaccines, one of which is myocarditis occurring with the FDA fully approved vaccine, Pfizer, and others.

Main body of the abstract: Certain miRNAs (non-coding RNA sequences) are involved in the pathogenesis in viral myocarditis, and those miRNAs are interestingly upregulated in severe COVID-19. We hypothesize that the use of mRNA-based vaccines may be triggering the release of host miRNAs or that trigger the occurrence of myocarditis. This is based on the finding of altered host miRNA expression promoting virus-induced myocarditis.

Short conclusion: In conclusion, miRNAs are likely implicated in myocarditis associated with mRNA vaccines. Our hypothesis suggests the use of miRNA as a biomarker for the diagnosis of mRNA vaccine-induced myocarditis. Additionally, the interplay between viral miRNA and the host immune system could alter inflammatory profiles, hence suggesting the use of therapeutic inhibition to prevent such complications.

Keywords: Micro-RNA; Myocarditis; Sarcopenia; mRNA COVID-19 vaccines.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

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Fig. 1
The potential role of micro-RNAs in mRNA-based vaccines. References: 1–56 as it is a summary of the article data
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