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. 2022 Nov 21;12(11):e062847.
doi: 10.1136/bmjopen-2022-062847.

Strengthening ethics committees for health-related research in sub-Saharan Africa: a scoping review

Iqra Chaudhry  1 , Val Thurtle  2 , Edward Foday  3 , Andrew J M Leather  2 , Mohamed Samai  4 , Haja Wurie  4 , Divya Parmar  5   2
Affiliations

Strengthening ethics committees for health-related research in sub-Saharan Africa: a scoping review

Iqra Chaudhry et al. BMJ Open. .

Abstract

Objective: Health-related research in sub-Saharan Africa (SSA) has grown over the years. However, concerns have been raised about the state of research ethics committees (RECs). This scoping review examines the literature on RECs for health-related research in SSA and identifies strategies that have been applied to strengthen the RECs. It focuses on three aspects of RECs: regulatory governance and leadership, administrative and financial capacity and technical capacity of members.

Design: A scoping review of published literature, including grey literature, was conducted using the Joanna Briggs Institute approach.

Data sources: BioOne, CINAHL, Embase (via Ovid), Education Abstracts, Global Health, Google Scholar, Jstor, OpenEdition (French), Philosopher's Index, PsycINFO, PubMed, Science Citation and Expanded Index (Web of Science), reference lists of included studies and specific grey literature sources.

Eligibility criteria: We included empirical studies on RECs for health-related research in SSA, covering topics on REC leadership and governance, administrative and financial capacity and the technical capacity of REC members. We included studies published between 01 January 2000 and 18 February 2022 and written in English, French, Portuguese or Swahili.

Data extraction and synthesis: Two independent reviewers screened the records. Data were extracted by one reviewer and cross-checked by another. Owing to the heterogeneity of included studies, thematic analysis was used.

Results: We included 54 studies. The findings show that most RECs in SSA work under significant administrative and financial constraints, with few opportunities for capacity building for committee members. This has an impact on the quality of reviews and the overall performance of RECs. Although most countries have national governance systems for RECs, they lack regulations on accountability, transparency and monitoring of RECs.

Conclusions: This review provides a comprehensive overview of the literature on RECs for health-related research in SSA and contributes to our understanding of how RECs can be strengthened.

Keywords: Health & safety; International health services; MEDICAL ETHICS.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
PRISMA flow diagram. PRISMA, Preferred Reporting Items for Systematic Review and Meta-Analysis; REC, research ethics committee.
Figure 2
Figure 2
Thematic map. RECs, research ethics committees; SSA, sub-Saharan Africa.
See this image and copyright information in PMC

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References

    1. Bryant JH, Harrison PF. Health research: essential link to equity in development, in Global Health in Transition: A Synthesis: Perspectives from International Organizations. National Academies Press (US), 1996. - PubMed
    1. Ndebele P, Wassenaar D, Benatar S, et al. . Research ethics capacity building in sub-Saharan Africa: a review of NIH Fogarty-funded programs 2000–2012. J Empir Res Hum Res Ethics 2014;9:24–40. 10.1525/jer.2014.9.2.24 - DOI - PMC - PubMed
    1. Alemayehu C, Mitchell G, Nikles J. Barriers for conducting clinical trials in developing countries- a systematic review. Int J Equity Health 2018;17:1–11. 10.1186/s12939-018-0748-6 - DOI - PMC - PubMed
    1. Ward CL, Shaw D, Sprumont D, et al. . Good collaborative practice: reforming capacity building governance of international health research partnerships. Global Health 2018;14:1–6. 10.1186/s12992-017-0319-4 - DOI - PMC - PubMed
    1. Ezeome ER, Simon C. Ethical problems in conducting research in acute epidemics: the pfizer meningitis study in Nigeria as an illustration. Dev World Bioeth 2010;10:1–10. 10.1111/j.1471-8847.2008.00239.x - DOI - PubMed

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