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Comment
. 2022 Nov 15;3(11):100809.
doi: 10.1016/j.xcrm.2022.100809.

Sugar and spice: Fc glycosylation in antibody-mediated transplant rejection

Nicole M Valenzuela  1
Affiliations
Comment

Sugar and spice: Fc glycosylation in antibody-mediated transplant rejection

Nicole M Valenzuela. Cell Rep Med. .

Abstract

Bharadwaj et al.1 demonstrate that anti-donor HLA antibodies display low levels of Fc fucosylation. This signature was associated with potent provocation of NK cell effector functions and was discriminative for active antibody-mediated rejection among patients with donor specific HLA antibodies.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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References

    1. Bharadwaj P.S., Sweta, Pongracz T., Concetta C., Sharma S., Le Moine, Alain, de Haan, Noortje, Murakami N., et al. Afucosylation of HLA-specific IgG1 as a potential predictor of antibody pathogenicity in kidney transplantation. Cell Reports Medicine. 2022 in press. - PMC - PubMed
    1. Valenzuela N.M., Schaub S. The Biology of IgG subclasses and their clinical relevance to transplantation. Transplantation. 2018;102(Suppl 1):S7–S13. doi: 10.1097/tp.0000000000001816. - DOI - PubMed
    1. Nimmerjahn F., Ravetch J.V. Divergent immunoglobulin g subclass activity through selective Fc receptor binding. Science. 2005;310:1510–1512. doi: 10.1126/science.1118948. - DOI - PubMed
    1. Shinkawa T., Nakamura K., Yamane N., Shoji-Hosaka E., Kanda Y., Sakurada M., Uchida K., Anazawa H., Satoh M., Yamasaki M., et al. The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity. J. Biol. Chem. 2003;278:3466–3473. doi: 10.1074/jbc.m210665200. - DOI - PubMed
    1. van Osch T.L.J., Nouta J., Derksen N.I.L., van Mierlo G., van der Schoot C.E., Wuhrer M., Rispens T., Vidarsson G. Fc galactosylation promotes Hexamerization of human IgG1, Leading to enhanced classical complement activation. J. Immunol. 2021;207:1545–1554. doi: 10.4049/jimmunol.2100399. - DOI - PMC - PubMed