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. 2022 Oct 15;41(4):549-558.
doi: 10.5937/jomb0-33222.

Intrahepatic cholestasis of pregnancy can increase the risk of metabolic disorders: A meta-analysis

Leiying Zhang  1 , Chen Tang  1 , Chenlian Ye  1 , Luren Huang  1 , Yan Wu  1
Affiliations

Intrahepatic cholestasis of pregnancy can increase the risk of metabolic disorders: A meta-analysis

Leiying Zhang et al. J Med Biochem. .

Abstract
in English, Serbian

Background: Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common complications during pregnancy. Studies indicated that abnormal bile acid metabolism is related to its pathogenesis. Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-specific liver disease, which classic symptoms include generalized pruritus that commonly and biochemical evidence of elevated bile acids. Our study aimed to explore the correlation between the ICP presence and risk of GDM, PE incident in pregnant women.

Methods: A meta-analysis, which included 10 eligible studies including 17,688 ICP cases and 1,386,771 controls, was performed to assess the correlation of ICP with preeclampsia (PE) and gestational diabetes mellitus (GDM). There were 7 studies investigating the relationship between ICP and PE, and 9 studies that evaluated the relationship between ICP and GDM. All eligible studies were screened from Pubmed, Web of Science and EBSCO databases.

Results: The results of this meta-analysis indicate that ICP significantly increase the risk for both PE (pooled odds ratio OR: 2.56 95%CI: 2.27 2.88, I2 heterogeneity = 35%, p heterogeneity = 0.16) and GDM (pooled OR: 2.28 95%CI: 1.69 3.07, I2 heterogeneity = 81%, p heterogeneity < 0.001). In the sensitivity analysis of GDM, excluding the largest heterogeneity study cannot change the result (pooled OR: 2.86 95%CI: 2.59 3.16, I2 heterogeneity = 0%, p heterogeneity = 0.56).

Conclusions: This meta-analysis shows that ICP is closely associated with ICP increased risk of PE and GDM) during pregnancy.

Uvod: Gestacijski dijabetes melitus (GDM) i preeklampsija (PE) su uobičajene komplikacije tokom trudnoće. Studije su pokazale da je abnormalni metabolizam žučne kiseline po vezan sa njegovom patogenezom. Intrahepatična holestaza u trudnći (ICP) je najčešća bolest jetre specifična za trudnoću, čiji klasični simptomi uključuju generalizovani svrab koji je uobičajen i biohemijski dokaz povišenih žučnih kiselina. Naša studija je imala za cilj da istraži korelaciju između prisustva ICP-a i rizika od GDM, PE incidenta kod trudnica.

Metode: Urađena je meta-analiza, koja je uključivala 10 prihvatljivih studija uključujući 17,688 slučajeva ICP i 386,771 kontrola, da bi se procenila korelacija ICP-a sa preeklampsijom (PE) i gestacijskim dijabetesom melitusom (GDM). Bilo je 7 studija koje su ispitivale odnos između ICP i PE, i 9 studija koje su procenile odnos između ICP i GDM. Sve studije koje ispunjavaju uslove su pregledane iz baza podataka Pubmed, Web of Science i EBSCO.

Keywords: gestational diabetes mellitus; intrahepatic cholestasis of pregnancy; preeclampsia.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors stated that they have no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1. Flow chart of the study selection procedure. A total of nine studies were included in our study.
Figure 2
Figure 2. Forest plots using a random-effects model: A) the relationship between ICP and PE, B) the relationship between ICP and GDM, and C) the relationship between ICP and GDM by excluding the most extensive heterogeneity study.
Figure 3
Figure 3. Funnel plots using a random-effects model: A) publication bias of the relationship between ICP and PE and B) publication bias of the relationship between ICP and GDM.
See this image and copyright information in PMC

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