Comment
doi: 10.1016/j.ceca.2022.102671.
Epub 2022 Nov 5.
Structural and functional conservation of the activating Ca2+ binding site in inositol 1,4.5-trisphosphate and ryanodine receptors
Affiliations
- PMID: 36370621
- DOI: 10.1016/j.ceca.2022.102671
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Comment
Structural and functional conservation of the activating Ca2+ binding site in inositol 1,4.5-trisphosphate and ryanodine receptors
Cell Calcium.
2022 Dec.
Abstract
Inositol 1,4,5-trisphosphate receptors (IP3Rs) and Ryanodine Receptors (RyRs) dictate the release of Ca2+ from the Endoplasmic (ER) and Sarcoplasmic Reticulum (SR). Arige et al [1] investigated the functional importance of specific Ca2+-coordinating residues, unambiguously confirming the activating Ca2+ binding site in the IP3R.
Keywords: Calcium binding site; Calcium release channels; Calcium signaling; Inositol 1,4,5-trisphosphate receptor; Ryanodine receptor.
Copyright © 2022 Elsevier Ltd. All rights reserved.
Comment on
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Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors.Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2209267119. doi: 10.1073/pnas.2209267119. Epub 2022 Sep 19. Proc Natl Acad Sci U S A. 2022. PMID: 36122240 Free PMC article.
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