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Review
. 2022 Nov 30;18(6):2143698.
doi: 10.1080/21645515.2022.2143698. Epub 2022 Nov 11.

The employment of vaccinia virus for colorectal cancer treatment: A review of preclinical and clinical studies

Qiaoyun Ling  1 , Bichun Zheng  1 , Xudong Chen  1 , Shaoshun Ye  1 , Quan Cheng  1
Affiliations
Review

The employment of vaccinia virus for colorectal cancer treatment: A review of preclinical and clinical studies

Qiaoyun Ling et al. Hum Vaccin Immunother. .

Abstract

Colorectal cancer (CRC) is one of the leading malignancies that causes death worldwide. Cancer vaccines and oncolytic immunotherapy bring new hope for patients with advanced CRC. The capability of vaccinia virus (VV) in carrying foreign genes as antigens or immunostimulatory factors has been demonstrated in animal models. VV of Wyeth, Western Reserve, Lister, Tian Tan, and Copenhagen strains have been engineered for the induction of antitumor response in multiple cancers. This paper summarized the preclinical and clinical application and development of VV serving as cancer vaccines and oncolytic vectors in CRC treatment. Additionally, the remaining challenges and future direction are also discussed.

Keywords: Vaccinia virus; cancer vaccine; clinical; colorectal cancer; oncolytic immunotherapy; preclinical.

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Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Figure 1.
Figure 1.
The strategies employed to improve the efficacy of VV for CRC treatment.
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The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.