The Anti-Inflammatory Effect of Novel Antidiabetic Agents

doi:10.3390/life12111829

Review

. 2022 Nov 9;12(11):1829.

doi: 10.3390/life12111829.

The Anti-Inflammatory Effect of Novel Antidiabetic Agents

Panagiotis Theofilis¹, Marios Sagris², Evangelos Oikonomou^{1

2}, Alexios S Antonopoulos¹, Gerasimos Siasos^{1

2}, Kostas Tsioufis¹, Dimitris Tousoulis¹

Affiliations

¹ 1st Cardiology Department, "Hippokration" General Hospital, University of Athens Medical School, 11527 Athens, Greece.
² 3rd Cardiology Department, Thoracic Diseases Hospital "Sotiria", University of Athens Medical School, 11527 Athens, Greece.

PMID: 36362984
PMCID: PMC9696750
DOI: 10.3390/life12111829

Review

The Anti-Inflammatory Effect of Novel Antidiabetic Agents

Panagiotis Theofilis et al. Life (Basel). 2022.

. 2022 Nov 9;12(11):1829.

doi: 10.3390/life12111829.

Authors

Panagiotis Theofilis¹, Marios Sagris², Evangelos Oikonomou^{1

2}, Alexios S Antonopoulos¹, Gerasimos Siasos^{1

2}, Kostas Tsioufis¹, Dimitris Tousoulis¹

Affiliations

¹ 1st Cardiology Department, "Hippokration" General Hospital, University of Athens Medical School, 11527 Athens, Greece.
² 3rd Cardiology Department, Thoracic Diseases Hospital "Sotiria", University of Athens Medical School, 11527 Athens, Greece.

PMID: 36362984
PMCID: PMC9696750
DOI: 10.3390/life12111829

Abstract

The incidence of type 2 diabetes (T2DM) has been increasing worldwide and remains one of the leading causes of atherosclerotic disease. Several antidiabetic agents have been introduced in trying to regulate glucose control levels with different mechanisms of action. These agents, and sodium-glucose cotransporter-2 inhibitors in particular, have been endorsed by contemporary guidelines in patients with or without T2DM. Their widespread usage during the last three decades has raised awareness in the scientific community concerning their pleiotropic mechanisms of action, including their putative anti-inflammatory effect. In this review, we delve into the anti-inflammatory role and mechanism of the existing antidiabetic agents in the cardiovascular system and their potential use in other chronic sterile inflammatory conditions.

Keywords: DPP4 inhibitors; GLP-1 receptor agonist; SGLT-2 inhibitor; diabetes mellitus; inflammation.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Oikonomou E., Leopoulou M., Theofilis P., Antonopoulos A.S., Siasos G., Latsios G., Mystakidi V.C., Antoniades C., Tousoulis D. A link between inflammation and thrombosis in atherosclerotic cardiovascular diseases: Clinical and therapeutic implications. Atherosclerosis. 2020;309:16–26. doi: 10.1016/j.atherosclerosis.2020.07.027. - DOI - PubMed
1. Sagris M., Theofilis P., Antonopoulos A.S., Oikonomou E., Paschaliori C., Galiatsatos N., Tsioufis K., Tousoulis D. Inflammation in Coronary Microvascular Dysfunction. Int. J. Mol. Sci. 2021;22:13471. doi: 10.3390/ijms222413471. - DOI - PMC - PubMed
1. Sagris M., Theofilis P., Antonopoulos A.S., Tsioufis C., Oikonomou E., Antoniades C., Crea F., Kaski J.C., Tousoulis D. Inflammatory Mechanisms in COVID-19 and Atherosclerosis: Current Pharmaceutical Perspectives. Int. J. Mol. Sci. 2021;22:6607. doi: 10.3390/ijms22126607. - DOI - PMC - PubMed
1. Adamo L., Rocha-Resende C., Prabhu S.D., Mann D.L. Reappraising the role of inflammation in heart failure. Nat. Rev. Cardiol. 2020;17:269–285. doi: 10.1038/s41569-019-0315-x. - DOI - PubMed
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[1] Oikonomou E., Leopoulou M., Theofilis P., Antonopoulos A.S., Siasos G., Latsios G., Mystakidi V.C., Antoniades C., Tousoulis D. A link between inflammation and thrombosis in atherosclerotic cardiovascular diseases: Clinical and therapeutic implications. Atherosclerosis. 2020;309:16–26. doi: 10.1016/j.atherosclerosis.2020.07.027. - DOI - PubMed

[2] Oikonomou E., Leopoulou M., Theofilis P., Antonopoulos A.S., Siasos G., Latsios G., Mystakidi V.C., Antoniades C., Tousoulis D. A link between inflammation and thrombosis in atherosclerotic cardiovascular diseases: Clinical and therapeutic implications. Atherosclerosis. 2020;309:16–26. doi: 10.1016/j.atherosclerosis.2020.07.027. - DOI - PubMed

[3] Sagris M., Theofilis P., Antonopoulos A.S., Oikonomou E., Paschaliori C., Galiatsatos N., Tsioufis K., Tousoulis D. Inflammation in Coronary Microvascular Dysfunction. Int. J. Mol. Sci. 2021;22:13471. doi: 10.3390/ijms222413471. - DOI - PMC - PubMed

[4] Sagris M., Theofilis P., Antonopoulos A.S., Oikonomou E., Paschaliori C., Galiatsatos N., Tsioufis K., Tousoulis D. Inflammation in Coronary Microvascular Dysfunction. Int. J. Mol. Sci. 2021;22:13471. doi: 10.3390/ijms222413471. - DOI - PMC - PubMed

[5] Sagris M., Theofilis P., Antonopoulos A.S., Tsioufis C., Oikonomou E., Antoniades C., Crea F., Kaski J.C., Tousoulis D. Inflammatory Mechanisms in COVID-19 and Atherosclerosis: Current Pharmaceutical Perspectives. Int. J. Mol. Sci. 2021;22:6607. doi: 10.3390/ijms22126607. - DOI - PMC - PubMed

[6] Sagris M., Theofilis P., Antonopoulos A.S., Tsioufis C., Oikonomou E., Antoniades C., Crea F., Kaski J.C., Tousoulis D. Inflammatory Mechanisms in COVID-19 and Atherosclerosis: Current Pharmaceutical Perspectives. Int. J. Mol. Sci. 2021;22:6607. doi: 10.3390/ijms22126607. - DOI - PMC - PubMed

[7] Adamo L., Rocha-Resende C., Prabhu S.D., Mann D.L. Reappraising the role of inflammation in heart failure. Nat. Rev. Cardiol. 2020;17:269–285. doi: 10.1038/s41569-019-0315-x. - DOI - PubMed

[8] Adamo L., Rocha-Resende C., Prabhu S.D., Mann D.L. Reappraising the role of inflammation in heart failure. Nat. Rev. Cardiol. 2020;17:269–285. doi: 10.1038/s41569-019-0315-x. - DOI - PubMed

[9] Murphy S.P., Kakkar R., McCarthy C.P., Januzzi J.L., Jr. Inflammation in Heart Failure: JACC State-of-the-Art Review. J. Am. Coll. Cardiol. 2020;75:1324–1340. doi: 10.1016/j.jacc.2020.01.014. - DOI - PubMed

[10] Murphy S.P., Kakkar R., McCarthy C.P., Januzzi J.L., Jr. Inflammation in Heart Failure: JACC State-of-the-Art Review. J. Am. Coll. Cardiol. 2020;75:1324–1340. doi: 10.1016/j.jacc.2020.01.014. - DOI - PubMed

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The Anti-Inflammatory Effect of Novel Antidiabetic Agents

Affiliations

The Anti-Inflammatory Effect of Novel Antidiabetic Agents

Authors

Affiliations

Abstract

Conflict of interest statement

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References

Publication types

Grants and funding

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