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Review
. 2022 Oct 28;13(11):1964.
doi: 10.3390/genes13111964.

Potential Mechanisms of Gut-Derived Extracellular Vesicle Participation in Glucose and Lipid Homeostasis

Tiange Feng  1 , Weizhen Zhang  1   2 , Ziru Li  3
Affiliations
Review

Potential Mechanisms of Gut-Derived Extracellular Vesicle Participation in Glucose and Lipid Homeostasis

Tiange Feng et al. Genes (Basel). .

Abstract

The intestine participates in the regulation of glucose and lipid metabolism in multiple facets. It is the major site of nutrient digestion and absorption, provides the interface as well as docking locus for gut microbiota, and harbors hormone-producing cells scattered throughout the gut epithelium. Intestinal extracellular vesicles are known to influence the local immune response, whereas their roles in glucose and lipid homeostasis have barely been explored. Hence, this current review summarizes the latest knowledge of cargo substances detected in intestinal extracellular vesicles, and connects these molecules with the fine-tuning regulation of glucose and lipid metabolism in liver, muscle, pancreas, and adipose tissue.

Keywords: extracellular vesicles; glucose metabolism; intestine; lipid metabolism; microbiota.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Gut-derived extracellular vesicles may participate in the regulation of lipid and glucose metabolism in remote organs. Extracellular vesicles originating from either intestinal epithelial cells or gut microbiota contain molecules that take part in the fine-tuning regulation of glucose and lipid homeostasis in liver, pancreases, and adipocytes.
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References

    1. Lötvall J., Hill A.F., Hochberg F., Buzás E.I., Di Vizio D., Gardiner C., Gho Y.S., Kurochkin I.V., Mathivanan S., Quesenberry P., et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles. J. Extracell. Vesicles. 2014;3:26913. doi: 10.3402/jev.v3.26913. - DOI - PMC - PubMed
    1. Van Niel G., D’Angelo G., Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat. Rev. Mol. Cell Biol. 2018;19:213–228. doi: 10.1038/nrm.2017.125. - DOI - PubMed
    1. Wang W., Zhu N., Yan T., Shi Y.-N., Chen J., Zhang C.-J., Xie X.-J., Liao D.-F., Qin L. The crosstalk: Exosomes and lipid metabolism. Cell Commun. Signal. 2020;18:119. doi: 10.1186/s12964-020-00581-2. - DOI - PMC - PubMed
    1. Huang Z., Xu A. Adipose Extracellular Vesicles in Intercellular and Inter-Organ Crosstalk in Metabolic Health and Diseases. Front. Immunol. 2021;12:608680. doi: 10.3389/fimmu.2021.608680. - DOI - PMC - PubMed
    1. Martin A.M., Sun E.W., Rogers G.B., Keating D.J. The Influence of the Gut Microbiome on Host Metabolism through the Regulation of Gut Hormone Release. Front. Physiol. 2019;10:428. doi: 10.3389/fphys.2019.00428. - DOI - PMC - PubMed

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