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Review
. 2022 Oct 28;11(21):3416.
doi: 10.3390/cells11213416.

The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease

Raymond C Harris  1   2
Affiliations
Review

The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease

Raymond C Harris. Cells. .

Abstract

The epidermal growth factor receptor (EGFR) is expressed in numerous cell types in the adult mammalian kidney and is activated by a family of EGF-like ligands. EGFR activation has been implicated in a variety of physiologic and pathophysiologic functions. There is increasing evidence that aberrant EGFR activation is a mediator of progressive kidney injury in diabetic kidney disease. This review will highlight recent studies indicating its potential role and mechanisms of injury of both glomerular and tubular cells in development and progression of diabetic kidney disease.

Keywords: EGF; diabetes; kidney; nephropathy.

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
EGFR activation leads to increased YAP translocation to the nucleus, association with TEAD and transcription of genes involved in progressive kidney injury.
See this image and copyright information in PMC

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References

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Publication types

Grants and funding

This research was funded by NIH grand DK51265 and funds from the Department of Veterans Affairs.