Ubiquitin-mediated mitochondrial regulation by MITOL/MARCHF5 at a glance
- PMID: 36346121
- DOI: 10.1093/jb/mvac092
Ubiquitin-mediated mitochondrial regulation by MITOL/MARCHF5 at a glance
Abstract
Mitochondria are involved in various cellular processes, such as energy production, inflammatory responses and cell death. Mitochondrial dysfunction is associated with many age-related diseases, including neurological disorders and heart failure. Mitochondrial quality is strictly maintained by mitochondrial dynamics linked to an adequate supply of phospholipids and other substances from the endoplasmic reticulum (ER). The outer mitochondrial membrane-localized E3 ubiquitin ligase MITOL/MARCHF5 is responsible for mitochondrial quality control through the regulation of mitochondrial dynamics, formation of mitochondria-ER contacts and mitophagy. MITOL deficiency has been shown to impair mitochondrial function, cause an excessive inflammatory response and increase vulnerability to stress, resulting in the exacerbation of the disease. In this study, we overview the ubiquitin-mediated regulation of mitochondrial function by MITOL and the relationship between MITOL and diseases.
Keywords: MITOL/MARCHF5; mitochondria-ER contacts; mitochondria.Abbreviations: AD, Alzheimer’s disease; CL, Cardiolipin; IMM, inner mitochondrial membrane; MERCs, mitochondria-ER contact sites (MERCs); MITOL, mitochondrial ubiquitin ligase; OMM, outer mitochondrial membrane; PA, phosphatidic acid; PS, phosphatidylserine; mitochondrial dynamics; ubiquitin.
© The Author(s) 2022. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.
Similar articles
-
MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.J Biochem. 2022 May 11;171(5):529-541. doi: 10.1093/jb/mvab153. J Biochem. 2022. PMID: 34964862
-
Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases.Int J Mol Sci. 2020 May 27;21(11):3781. doi: 10.3390/ijms21113781. Int J Mol Sci. 2020. PMID: 32471110 Free PMC article. Review.
-
MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2.Mol Cell. 2013 Jul 11;51(1):20-34. doi: 10.1016/j.molcel.2013.04.023. Epub 2013 May 30. Mol Cell. 2013. PMID: 23727017
-
MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress.Life Sci Alliance. 2019 Aug 15;2(4):e201900308. doi: 10.26508/lsa.201900308. Print 2019 Aug. Life Sci Alliance. 2019. PMID: 31416892 Free PMC article.
-
Roles of mitochondrial ubiquitin ligase MITOL/MARCH5 in mitochondrial dynamics and diseases.J Biochem. 2014 May;155(5):273-9. doi: 10.1093/jb/mvu016. Epub 2014 Mar 9. J Biochem. 2014. PMID: 24616159 Review.
Cited by
-
The Role of Cardiolipin in Brain Bioenergetics, Neuroinflammation, and Neurodegeneration.Mol Neurobiol. 2024 Nov 19. doi: 10.1007/s12035-024-04630-6. Online ahead of print. Mol Neurobiol. 2024. PMID: 39557801 Review.
-
BioE3 identifies specific substrates of ubiquitin E3 ligases.Nat Commun. 2023 Nov 23;14(1):7656. doi: 10.1038/s41467-023-43326-8. Nat Commun. 2023. PMID: 37996419 Free PMC article.
-
Exploring the Role of Ubiquitin-Proteasome System in the Pathogenesis of Parkinson's Disease.Pharmaceuticals (Basel). 2024 Jun 14;17(6):782. doi: 10.3390/ph17060782. Pharmaceuticals (Basel). 2024. PMID: 38931449 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
