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Review
. 2022 Oct 14:9:988843.
doi: 10.3389/fsurg.2022.988843. eCollection 2022.

3D bioprinted mesenchymal stromal cells in skin wound repair

Yuansen Luo  1 , Xuefeng Xu  1 , Zhiming Ye  1 , Qikun Xu  1 , Jin Li  1 , Ning Liu  1 , Yongjun Du  1
Affiliations
Review

3D bioprinted mesenchymal stromal cells in skin wound repair

Yuansen Luo et al. Front Surg. .

Abstract

Skin tissue regeneration and repair is a complex process involving multiple cell types, and current therapies are limited to promoting skin wound healing. Mesenchymal stromal cells (MSCs) have been proven to enhance skin tissue repair through their multidifferentiation and paracrine effects. However, there are still difficulties, such as the limited proliferative potential and the biological processes that need to be strengthened for MSCs in wound healing. Recently, three-dimensional (3D) bioprinting has been applied as a promising technology for tissue regeneration. 3D-bioprinted MSCs could maintain a better cell ability for proliferation and expression of biological factors to promote skin wound healing. It has been reported that 3D-bioprinted MSCs could enhance skin tissue repair through anti-inflammatory, cell proliferation and migration, angiogenesis, and extracellular matrix remodeling. In this review, we will discuss the progress on the effect of MSCs and 3D bioprinting on the treatment of skin tissue regeneration, as well as the perspective and limitations of current research.

Keywords: 3D bioprinting; biological engineering; mesenchymal stromal cells; paracrine; skin tissue regeneration.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
MSCs promote skin tissue regeneration through anti-inflammatory and immunoregulatory, cell migration and proliferation, angiogenesis, and ECM remodeling. MSCs, mesenchymal stromal cells; ECM, extracellular matrix.
Figure 2
Figure 2
There are multiple strategies of 3D bioprinting, including inkjet bioprinting (A), laser bioprinting (B), extrusion-based bioprinting (C), SLA-based bioprinting (D), and DLP-based bioprinting (E). DLP, digital light processing; SLA, stereolithography.
Figure 3
Figure 3
3D-bioprinted MSCs promote skin tissue regeneration. MSCs, mesenchymal stromal cells
See this image and copyright information in PMC

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