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Review
. 2022 Oct 13:9:996057.
doi: 10.3389/fmolb.2022.996057. eCollection 2022.

Molecular regulation after mucosal injury and regeneration in ulcerative colitis

Lie Zheng  1 , Sheng-Lei Duan  1 , Xin-Li Wen  1 , Yan-Cheng Dai  2
Affiliations
Review

Molecular regulation after mucosal injury and regeneration in ulcerative colitis

Lie Zheng et al. Front Mol Biosci. .

Abstract

Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with a complex etiology. Intestinal mucosal injury is an important pathological change in individuals with UC. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5+) intestinal stem cells (ISCs) exhibit self-renewal and high differentiation potential and play important roles in the repair of intestinal mucosal injury. Moreover, LGR5+ ISCs are intricately regulated by both the Wnt/β-catenin and Notch signaling pathways, which jointly maintain the function of LGR5+ ISCs. Combination therapy targeting multiple signaling pathways and transplantation of LGR5+ ISCs may lead to the development of new clinical therapies for UC.

Keywords: intestinal stem cells; molecular regulation; mucosal injury; regeneration; ulcerative colitis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
EGF signaling.
FIGURE 2
FIGURE 2
Hippo-YES-associated protein (YAP) pathway.
FIGURE 3
FIGURE 3
Notch signaling pathway.
FIGURE 4
FIGURE 4
BMP signaling pathway.
FIGURE 5
FIGURE 5
Mechanisms of action of Wnt/β-catenin signaling pathways.
See this image and copyright information in PMC

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