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Review
. 2022 Oct 6:13:976385.
doi: 10.3389/fphar.2022.976385. eCollection 2022.

Multifunctional role of natural products for the treatment of Parkinson's disease: At a glance

Md Mominur Rahman  1 , Xiaoyan Wang  2 , Md Rezaul Islam  1 , Shopnil Akash  1 , Fatema Akter Supti  1 , Mohona Islam Mitu  1 , Md Harun-Or-Rashid  1 , Most Nazmin Aktar  1 , Most Sumaiya Khatun Kali  1 , Farhana Israt Jahan  1 , Rajeev K Singla  3   4 , Bairong Shen  3 , Abdur Rauf  5 , Rohit Sharma  6
Affiliations
Review

Multifunctional role of natural products for the treatment of Parkinson's disease: At a glance

Md Mominur Rahman et al. Front Pharmacol. .

Abstract

Natural substances originating from plants have long been used to treat neurodegenerative disorders (NDs). Parkinson's disease (PD) is a ND. The deterioration and subsequent cognitive impairments of the midbrain nigral dopaminergic neurons distinguish by this characteristic. Various pathogenic mechanisms and critical components have been reported, despite the fact that the origin is unknown, such as protein aggregation, iron buildup, mitochondrial dysfunction, neuroinflammation and oxidative stress. Anti-Parkinson drugs like dopamine (DA) agonists, levodopa, carbidopa, monoamine oxidase type B inhibitors and anticholinergics are used to replace DA in the current treatment model. Surgery is advised in cases where drug therapy is ineffective. Unfortunately, the current conventional treatments for PD have a number of harmful side effects and are expensive. As a result, new therapeutic strategies that control the mechanisms that contribute to neuronal death and dysfunction must be addressed. Natural resources have long been a useful source of possible treatments. PD can be treated with a variety of natural therapies made from medicinal herbs, fruits, and vegetables. In addition to their well-known anti-oxidative and anti-inflammatory capabilities, these natural products also play inhibitory roles in iron buildup, protein misfolding, the maintenance of proteasomal breakdown, mitochondrial homeostasis, and other neuroprotective processes. The goal of this research is to systematically characterize the currently available medications for Parkinson's and their therapeutic effects, which target diverse pathways. Overall, this analysis looks at the kinds of natural things that could be used in the future to treat PD in new ways or as supplements to existing treatments. We looked at the medicinal plants that can be used to treat PD. The use of natural remedies, especially those derived from plants, to treat PD has been on the rise. This article examines the fundamental characteristics of medicinal plants and the bioactive substances found in them that may be utilized to treat PD.

Keywords: Parkinson’s disease; medicinal plants; natural products; neurodegeneration; neuroinflammation; pathways; treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor HB declared a past collaboration with the author RS.

Figures

FIGURE 1
FIGURE 1
Different types of pathway for neurodegeneration in PD by LB, caspase activation and releasing different types of inflammatory cytokine.
FIGURE 2
FIGURE 2
Disorders associated with parkinsonian patient like supranuclear palsy, LB multiple system atrophy and corticobasal degeneration.
FIGURE 3
FIGURE 3
PD with different types of sleep disorder like sleep fragmentation, REM (Rapid Eye Movement), Breathing problem during sleep (Apnea), increase daytime sleep and finally depression.
See this image and copyright information in PMC

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