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Review
. 2022 Sep 21;24(5):391.
doi: 10.3892/ol.2022.13511. eCollection 2022 Nov.

Mechanism of action of CTRP6 in the regulation of tumorigenesis in the digestive system

Aimin Zhang  1 , Mowei Kong  2 , Xiuyun Zhang  1 , Zhenying Pei  2
Affiliations
Review

Mechanism of action of CTRP6 in the regulation of tumorigenesis in the digestive system

Aimin Zhang et al. Oncol Lett. .

Abstract

Tumors of the digestive system have always received attention, and their occurrence and development are regulated by various mechanisms such as inflammation and immunity, glucose and lipid metabolism, and tumor angiogenesis. Complement Clq/TNF-related protein 6 (CTRP6) is a member of the CTRP family; it is widely expressed in various tissues and cell types, and plays a biological role in a number of mechanisms, such as glucose and lipid metabolism and inflammation. Recent studies have revealed the tumor-promoting effect of CTRP6 in gastric cancer, liver cancer, colorectal cancer and other gastrointestinal tumors, but, to the best of our knowledge, there has been no systematic discussion on the tumor-promoting mechanism of CTRP6. The present study reviews the role of CTRP6 in tumors of the digestive system and its possible mechanisms.

Keywords: C1qTNF-related protein 6; colon cancer; gastric cancer; protein kinase B.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1.
Figure 1.
Schematic structure of complement Clq/TNF proteins.
Figure 2.
Figure 2.
CTRP6 enhances tumor invasion and migration through the activation of the MAPK and Akt pathways. CTRP6, C1qTNF-related protein 6.
Figure 3.
Figure 3.
CTRP6 enhances tumor cell proliferation and metastasis by regulating glycolipid metabolism through the activation of the Akt/PKA/MAPK pathway. PKA, protein kinase A; IGF, insulin-like growth factor; C1qTNF-related protein 6.
Figure 4.
Figure 4.
CTRP6 regulates tumor angiogenesis through the activation of the PI3K/Akt pathway. C1qTNF-related protein 6.
Figure 5.
Figure 5.
Summary of CTRP6 pathways regulating digestive system tumors. IGF, insulin-like growth factor; C1qTNF-related protein 6.
See this image and copyright information in PMC

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Funding: No funding was received.