Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct;54(10):1643-1651.
doi: 10.1038/s12276-022-00824-x. Epub 2022 Oct 21.

New insights into the epitranscriptomic control of pluripotent stem cell fate

Young Hyun Che #  1 , Hojae Lee #  2 , Yong Jun Kim  3   4   5
Affiliations
Review

New insights into the epitranscriptomic control of pluripotent stem cell fate

Young Hyun Che et al. Exp Mol Med. 2022 Oct.

Abstract

Each cell in the human body has a distinguishable fate. Pluripotent stem cells are challenged with a myriad of lineage differentiation options. Defects are more likely to be fatal to stem cells than to somatic cells due to the broad impact of the former on early development. Hence, a detailed understanding of the mechanisms that determine the fate of stem cells is needed. The mechanisms by which human pluripotent stem cells, although not fully equipped with complex chromatin structures or epigenetic regulatory mechanisms, accurately control gene expression and are important to the stem cell field. In this review, we examine the events driving pluripotent stem cell fate and the underlying changes in gene expression during early development. In addition, we highlight the role played by the epitranscriptome in the regulation of gene expression that is necessary for each fate-related event.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Dynamics of stem cell development.
a Morphological changes of stem cells according to the stage of stem cell development. b Molecular mechanism in the acquisition of heterogeneity. c Pluripotent state of stem cells derived during different developmental stages. d Molecular characteristics during stem cell development.
Fig. 2
Fig. 2. Various features of pluripotent stem cells are regulated by epitranscriptomic modifications.
Molecular regulatory functions of epitranscriptomic modification m6A (red), m1A (yellow), pseudouridine (green), and m5C (blue) are associated with each biological phenotype in pluripotent stem cells.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Fuchs E, Segre JA. Stem cells: a new lease on life. Cell. 2000;100:143–155. - PubMed
    1. Winickoff DE, Saha K, Graff GD. Opening stem cell research and development: a policy proposal for the management of data, intellectual property, and ethics. Yale J. Health Policy Law Ethics. 2009;9:52–127. - PubMed
    1. Stent GS. The role of cell lineage in development. Philos. Trans. R. Soc. Lond. B Biol. Sci. 1985;312:3–19. - PubMed
    1. Wobus AM, Boheler KR. Embryonic stem cells: prospects for developmental biology and cell therapy. Physiol. Rev. 2005;85:635–678. - PubMed
    1. Yun W, Kim YJ, Lee G. Direct conversion to achieve glial cell fates: oligodendrocytes and Schwann cells. Int. J. Stem Cells. 2022;15:14–25. - PMC - PubMed

Publication types

MeSH terms