Clinical Trial
Double-blind study of ketoprofen and indomethacin in juvenile chronic arthritis
- PMID: 362571
Item in Clipboard
Clinical Trial
Double-blind study of ketoprofen and indomethacin in juvenile chronic arthritis
S Afr Med J.
.
Abstract
Ketoprofen (Orudis; Maybaker), whose use has not previously been reported in choldren, was compared with indomethacin in a double-blind crossover trial in 30 children with juvenile chronic arthritis. Both drugs proved to be safe and effective analgesics and anti-inflammatory agents although indomethacin emerged as the preferred drug. Perhaps higher doses of ketoprofen would be safe and more effective. Side-effects were few and mild. The problems of patient compliance and the assessment of pain in children are discussed.
Similar articles
-
Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study.J Rheumatol. 1988 Sep;15(9):1422-6. J Rheumatol. 1988. PMID: 3058974 Clinical Trial.
-
[Double-blind comparative study of slow-release ketoprofen tablets and indomethacin in coxarthrosis and gonarthrosis].Sem Hop. 1983 Dec 12;59(46):3243-5. Sem Hop. 1983. PMID: 6318351 Clinical Trial. French.
-
A double-blind crossover comparison of Orudis (ketoprofen) and indomethacin in the treatment of rheumatoid arthritis.J Int Med Res. 1976;4(6):427-31. doi: 10.1177/030006057600400608. J Int Med Res. 1976. PMID: 800382 Clinical Trial.
-
Ketoprofen: a review of its pharmacologic and clinical properties.Pharmacotherapy. 1986 May-Jun;6(3):93-103. doi: 10.1002/j.1875-9114.1986.tb03459.x. Pharmacotherapy. 1986. PMID: 3526298 Review.
-
[Clinical experimental research on the use of 2-(3-benzoylphenyl) propionic acid, or Ketoprofen, an adjuvant of antibiotic action in oral surgery].Riv Ital Stomatol. 1978 Jul-Aug;47(7-8):14-25. Riv Ital Stomatol. 1978. PMID: 368951 Review. Italian. No abstract available.
Cited by
-
Antipyretic effect of ketoprofen.Indian J Pediatr. 2009 Mar;76(3):287-91. doi: 10.1007/s12098-008-0234-z. Epub 2009 Jan 5. Indian J Pediatr. 2009. PMID: 19129989 Clinical Trial.
-
Risks and benefits of nonsteroidal anti-inflammatory drugs in children: a comparison with paracetamol.Paediatr Drugs. 2001;3(11):817-58. doi: 10.2165/00128072-200103110-00004. Paediatr Drugs. 2001. PMID: 11735667 Review.
-
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.Paediatr Drugs. 2022 Nov;24(6):603-655. doi: 10.1007/s40272-022-00514-1. Epub 2022 Sep 2. Paediatr Drugs. 2022. PMID: 36053397 Free PMC article. Review.
-
Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents.Cochrane Database Syst Rev. 2017 Aug 2;8(8):CD012537. doi: 10.1002/14651858.CD012537.pub2. Cochrane Database Syst Rev. 2017. PMID: 28770976 Free PMC article. Review.
-
Clinical pharmacokinetics of drugs used in juvenile arthritis.Clin Pharmacokinet. 1991 Aug;21(2):129-49. doi: 10.2165/00003088-199121020-00004. Clin Pharmacokinet. 1991. PMID: 1884567 Review.