Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR

doi:10.1007/978-3-031-12390-0_6

. 2023:29:163-184.

doi: 10.1007/978-3-031-12390-0_6.

Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR

Yoshiki Yamaguchi¹, Takumi Yamaguchi^{2

3}, Koichi Kato^{4

5}

Affiliations

¹ Division of Structural Biology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan. yyoshiki@tohoku-mpu.ac.jp.
² School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Japan.
³ Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Japan.
⁴ Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Japan. kkatonmr@ims.ac.jp.
⁵ Exploratory Research Center on Life and Living Systems and Institute for Molecular Science, Okazaki, Japan. kkatonmr@ims.ac.jp.

PMID: 36255675
DOI: 10.1007/978-3-031-12390-0_6

Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR

Yoshiki Yamaguchi et al. Adv Neurobiol. 2023.

. 2023:29:163-184.

doi: 10.1007/978-3-031-12390-0_6.

Authors

Yoshiki Yamaguchi¹, Takumi Yamaguchi^{2

3}, Koichi Kato^{4

5}

Affiliations

¹ Division of Structural Biology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan. yyoshiki@tohoku-mpu.ac.jp.
² School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Japan.
³ Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Japan.
⁴ Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Japan. kkatonmr@ims.ac.jp.
⁵ Exploratory Research Center on Life and Living Systems and Institute for Molecular Science, Okazaki, Japan. kkatonmr@ims.ac.jp.

PMID: 36255675
DOI: 10.1007/978-3-031-12390-0_6

Abstract

Carbohydrate chains play critical roles in cellular recognition and subsequent signal transduction in the nervous system. Furthermore, gangliosides are targets for various amyloidogenic proteins associated with neurodegenerative disorders. To better understand the molecular mechanisms underlying these biological phenomena, atomic views are essential to delineate dynamic biomolecular interactions. Nuclear magnetic resonance (NMR) spectroscopy provides powerful tools for studying structures, dynamics, and interactions of biomolecules at the atomic level. This chapter describes the basics of solution NMR techniques and their applications to the analysis of 3D structures and interactions of glycoconjugates in the nervous system.

Keywords: Dynamics; Glycolipid; Interaction; Nuclear magnetic resonance; Oligosaccharide; Structure.

PubMed Disclaimer

References

1. Abragam A. The principles of nuclear magnetism. The international series of monographs on physics. Oxford: Clarendon; 1961.
1. Acquotti D, Poppe L, Dabrowski J, von der Lieth CW, Sonnino S, Tettamanti G. Three-dimensional structure of the oligosaccharide chain of GM1 ganglioside revealed by a distance-mapping procedure: a rotating and laboratory frame nuclear overhauser enhancement investigation of native glycolipid in dimethyl sulfoxide and in water- dodecylphosphocholine solutions. J Am Chem Soc. 1990;112(21):7772–8. - DOI
1. Alessenko AV, Albi E. Exploring sphingolipid implications in neurodegeneration. Front Neurol. 2020;11:437. - PubMed - PMC - DOI
1. Ardá A, Jiménez-Barbero J. The recognition of glycans by protein receptors. Insights from NMR spectroscopy. Chem Commun. 2018;54(38):4761–9. - DOI
1. Ariga T, McDonald MP, Yu RK. Role of ganglioside metabolism in the pathogenesis of Alzheimer’s disease – a review. J Lipid Res. 2008;49(6):1157–75. - PubMed - PMC - DOI

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions

[1] Abragam A. The principles of nuclear magnetism. The international series of monographs on physics. Oxford: Clarendon; 1961.

[2] Abragam A. The principles of nuclear magnetism. The international series of monographs on physics. Oxford: Clarendon; 1961.

[3] Acquotti D, Poppe L, Dabrowski J, von der Lieth CW, Sonnino S, Tettamanti G. Three-dimensional structure of the oligosaccharide chain of GM1 ganglioside revealed by a distance-mapping procedure: a rotating and laboratory frame nuclear overhauser enhancement investigation of native glycolipid in dimethyl sulfoxide and in water- dodecylphosphocholine solutions. J Am Chem Soc. 1990;112(21):7772–8. - DOI

[4] Acquotti D, Poppe L, Dabrowski J, von der Lieth CW, Sonnino S, Tettamanti G. Three-dimensional structure of the oligosaccharide chain of GM1 ganglioside revealed by a distance-mapping procedure: a rotating and laboratory frame nuclear overhauser enhancement investigation of native glycolipid in dimethyl sulfoxide and in water- dodecylphosphocholine solutions. J Am Chem Soc. 1990;112(21):7772–8. - DOI

[5] Alessenko AV, Albi E. Exploring sphingolipid implications in neurodegeneration. Front Neurol. 2020;11:437. - PubMed - PMC - DOI

[6] Alessenko AV, Albi E. Exploring sphingolipid implications in neurodegeneration. Front Neurol. 2020;11:437. - PubMed - PMC - DOI

[7] Ardá A, Jiménez-Barbero J. The recognition of glycans by protein receptors. Insights from NMR spectroscopy. Chem Commun. 2018;54(38):4761–9. - DOI

[8] Ardá A, Jiménez-Barbero J. The recognition of glycans by protein receptors. Insights from NMR spectroscopy. Chem Commun. 2018;54(38):4761–9. - DOI

[9] Ariga T, McDonald MP, Yu RK. Role of ganglioside metabolism in the pathogenesis of Alzheimer’s disease – a review. J Lipid Res. 2008;49(6):1157–75. - PubMed - PMC - DOI

[10] Ariga T, McDonald MP, Yu RK. Role of ganglioside metabolism in the pathogenesis of Alzheimer’s disease – a review. J Lipid Res. 2008;49(6):1157–75. - PubMed - PMC - DOI

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR

Affiliations

Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR

Authors

Affiliations

Abstract

Similar articles

References

MeSH terms

Substances