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Review
. 2022 Oct 5;27(19):6596.
doi: 10.3390/molecules27196596.

New Advances in Lateral Flow Immunoassay (LFI) Technology for Food Safety Detection

Guangxu Xing  1 , Xuefeng Sun  1 , Ning Li  2 , Xuewu Li  1 , Tiantian Wu  2 , Fangyu Wang  1
Affiliations
Review

New Advances in Lateral Flow Immunoassay (LFI) Technology for Food Safety Detection

Guangxu Xing et al. Molecules. .

Abstract

With the continuous development of China's economy and society, people and the government have higher and higher requirements for food safety. Testing for food dopants and toxins can prevent the occurrence of various adverse health phenomena in the world's population. By deploying new and powerful sensors that enable rapid sensing processes, the food industry can help detect trace adulteration and toxic substances. At present, as a common food safety detection method, lateral flow immunochromatography (LFI) is widely used in food safety testing, environmental testing and clinical medical treatment because of its advantages of simplicity, speed, specificity and low cost, and plays a pivotal role in ensuring food safety. This paper mainly focuses on the application of lateral flow immunochromatography and new technologies combined with test strips in food safety detection, such as aptamers, surface-enhanced Raman spectroscopy, quantum dots, electrochemical test strip detection technology, biosensor test strip detection, etc. In addition, sensing principles such as fluorescence resonance energy transfer can also more effective. Different methods have different characteristics. The following is a review of the application of these technologies in food safety detection.

Keywords: FRET; LFI; QDs; SERS; aptamer; biosensors; electrochemical sensors.

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Conflict of interest statement

Guangxu Xing, Xuefeng Sun, Ning Li, Xuewu Li, Tiantian Wu, Fangyu Wang declare that they have no conflict of interest or financial conflict to disclose.

Figures

Figure 1
Figure 1
One of the detection principles of LFI–FRET.
Figure 2
Figure 2
The detection technology of LFI–Aptamer.
Figure 3
Figure 3
The detection technology of LFI–SERS.
Figure 4
Figure 4
The detection technology of LFI–QDs.
Figure 5
Figure 5
The detection technology of LFI–Electrochemical sensor.
Figure 6
Figure 6
The detection technology of LFI–Biosensor.
See this image and copyright information in PMC

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Grants and funding

This research was supported by the National Key Research and Development Program of China (2019YFC1605700).