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Review
. 2022 Sep 30;11(19):3075.
doi: 10.3390/cells11193075.

Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases

Hezhen Chu  1 , Zhenqian Qin  2 , Jun Ma  1 , Yimin Xie  2 , Haifeng Shi  3 , Jie Gu  3 , Baiqiang Shi  1
Affiliations
Review

Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases

Hezhen Chu et al. Cells. .

Abstract

The calcium-sensing receptor (CaSR), a G-protein-coupled receptor (GPCR), is a cell-surface-located receptor that can induce highly diffusible messengers (IP3, Ca2+, cAMP) in the cytoplasm to activate various cellular responses. Recently, it has also been suggested that the CaSR mediates the intracellular communications between the endoplasmic reticulum (ER), mitochondria, nucleus, protease/proteasome, and autophagy-lysosome, which are involved in related cardiovascular diseases. The complex intracellular signaling of this receptor challenges it as a valuable therapeutic target. It is, therefore, necessary to understand the mechanisms behind the signaling characteristics of this receptor in intracellular communication. This review provides an overview of the recent research progress on the various regulatory mechanisms of the CaSR in related cardiovascular diseases and the heart-kidney interaction; the associated common causes are also discussed.

Keywords: calcium-sensing receptor; cardiovascular diseases; lysosome; mitochondria; nucleus; proteasome.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
CaSR signaling mediates cardiovascular diseases. The activation regulator is in red color, and the negative modulator is in green color.
Figure 2
Figure 2
CaSR-mediated signaling in cardiorenal syndrome and heart–kidney interaction. The activation regulator is in red color, and the negative modulator is in green color.
See this image and copyright information in PMC

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Grants and funding

This research was funded by the Science and Technology Development Medical and Health Guidance Plan Project of Yixing City (202038), the Science and Technology Development Medical and Health Guidance Plan Project of Wuxi City (202061), the Science and Technology Innovation (Social Development) Project of Yixing Science and Technology Bureau (2020SF08), and the Scientific and Technological Achievements and Suitable Technology Promotion Project of Wuxi Health Commission (T202126).

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