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Review
. 2022 Sep 21:13:956173.
doi: 10.3389/fphar.2022.956173. eCollection 2022.

Traditional chinese medicine to prevent and treat diabetic erectile dysfunction

Yanfei Feng  1 , Tianhao Shi  1 , Yuli Fu  1 , Bodong Lv  2   3
Affiliations
Review

Traditional chinese medicine to prevent and treat diabetic erectile dysfunction

Yanfei Feng et al. Front Pharmacol. .

Abstract

Diabetic erectile dysfunction (DED) is one of the most common complications of diabetes mellitus. However, current therapeutics have no satisfactory effect on DED. In recent years, traditional Chinese medicine (TCM) has shown good effects against DED. By now, several clinical trials have been conducted to study the effect of TCM in treating DED; yet, the underlying mechanism is not fully investigated. Therefore, in this review, we briefly summarized the pathophysiological mechanism of DED and reviewed the published clinical trials on the treatment of DED by TCM. Then, the therapeutic potential of TCM and the underlying mechanisms whereby TCM exerts protective effects were summarized. We concluded that TCM is more effective than chemical drugs in treating DED by targeting multiple signaling pathways, including those involved in oxidation, apoptosis, atherosclerosis, and endothelial function. However, the major limitation in the application of TCM against DED is the lack of a large-scale, multicenter, randomized, and controlled clinical trial on the therapeutic effect, and the underlying pharmaceutical mechanisms also need further investigation. Despite these limitations, clinical trials and further experimental studies will enhance our understanding of the mechanisms modulated by TCM and promote the widespread application of TCM to treat DED.

Keywords: Chinese herbs; diabetic erectile dysfunction; endothelial dysfunction; oxidative stress; traditional Chinese medicine; vasculopathy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic of the mechanisms involved in the etiology of diabetic vascular complications. (A) Cross-sectional pattern of the penis. (B) Under the physiological conditions, nitric oxide (NO) is generated by the corporal endothelial cells and stimulates the smooth muscle to produce cyclic guanosine monophosphate (cGMP), which dilates the vascular smooth muscle of the corpora cavernosa and thereby facilitates the blood supply resulting in erection. (C) Hyperglycemia promotes oxidative stress and the formation of advanced glycation end products (AGEs) and oxidized low-density lipoprotein (ox-LDL). Consequently, the permeability of the vascular endothelium and the production of reactive oxygen species (ROS) are increased. ROS can downregulate NO via inhibiting the activity of endothelial nitric oxide synthase (eNOS). Additionally, the activation of the polyol pathway impairs neurovascular function via suppressing the activity of neuronal nitric oxide synthase (nNOS). Further, the accumulation of AGEs and ox-LDL causes vascular thickening and atherosclerosis in the cavernous sinusoid. Finally, the prolonged oxidative stress can also induce apoptosis.
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