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Review
. 2022 Sep 20:13:923387.
doi: 10.3389/fimmu.2022.923387. eCollection 2022.

Proteomic insights into SARS-CoV-2 infection mechanisms, diagnosis, therapies and prognostic monitoring methods

Shengman Yu  1   2 , Xiaoyan Li  3 , Zhuoyuan Xin  4 , Liyuan Sun  2 , Jingwei Shi  1
Affiliations
Review

Proteomic insights into SARS-CoV-2 infection mechanisms, diagnosis, therapies and prognostic monitoring methods

Shengman Yu et al. Front Immunol. .

Abstract

At the end of 2019, the COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, seriously damaged world public health security. Several protein markers associated with virus infection have been extensively explored to combat the ever-increasing challenge posed by SARS-CoV-2. The proteomics of COVID-19 deepened our understanding of viral particles and their mechanisms of host invasion, providing us with information on protein changes in host tissues, cells and body fluids following infection in COVID-19 patients. In this review, we summarize the proteomic studies of SARS-CoV-2 infection and review the current understanding of COVID-19 in terms of the quantitative and qualitative proteomics of viral particles and host entry factors from the perspective of protein pathological changes in the organism following host infection.

Keywords: COVID-19; SARS-CoV-2; protein biomarker; proteomics; virus infection.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Proteomics study detects variations of protein expression in different organs infected by SARS-CoV-2 (Hair follicle, brain, heart, lung, liver, kidney, gut, skin and peripheral are shown in schematic).
See this image and copyright information in PMC

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