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Randomized Controlled Trial
. 2022 Sep 10;14(18):3736.
doi: 10.3390/nu14183736.

Acute Flaxseed Intake Reduces Postprandial Glycemia in Subjects with Type 2 Diabetes: A Randomized Crossover Clinical Trial

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Randomized Controlled Trial

Acute Flaxseed Intake Reduces Postprandial Glycemia in Subjects with Type 2 Diabetes: A Randomized Crossover Clinical Trial

Fernanda Duarte Moreira et al. Nutrients. .

Abstract

Background: Postprandial glycemic excursions are associated with impairment control of diabetes mellitus. Long-term consumption of flaxseed can lower blood glucose levels; however, its effects on the postprandial glycemic response remain unknown. Therefore, this study aimed to evaluate the acute effects of raw flaxseed consumption on the 2 h postprandial glycemic curve in men with type 2 diabetes mellitus (T2DM). Methods: This was a randomized crossover clinical trial. Nineteen men with T2DM were randomly assigned a standardized breakfast without (control) or with a previous intake of 15 g of ground raw golden flaxseed (flax). Glycemia was measured at fasting and postprandial at 15, 30, 45, 60, 90, and 120 min. Palatability markers (visual appeal, smell, and pleasantness of taste) and taste intensity (sweetness, saltiness, bitterness, sourness, and creaminess) were evaluated. Results: The peak glucose rise and the 2 h AUC glycemic response reduced in the flax group by 17% (p = 0.001) and 24% (p < 0.001), respectively. The glucose peak time, palatability, and taste parameters did not differ between the two groups. Conclusions: Ingestion of 15 g of ground raw golden flaxseed before breakfast decreases the 2 h postprandial glycemic response in men with T2DM.

Keywords: complex carbohydrates; diabetes mellitus; dietary fiber; flaxseed; postprandial blood glucose.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Study participants’ flowchart (n = 19).
Figure 2
Figure 2
Postprandial glycemic responses of men with T2DM in the control and raw flaxseed groups. (A) Glucose peak rise in men with T2DM after ingesting a breakfast containing 50 g of complex carbohydrates either without (control) or with (flax) prior intake of 15 g of raw flaxseed, (B) area under the glycemic curve (AUC; mg/dL/min), and (C) glycemic curve. * p ≤ 0.001 vs. control; # p = 0.03 vs. control; γ p = 0.072 vs. control.

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