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Review
. 2022 Aug 31;10(9):2137.
doi: 10.3390/biomedicines10092137.

Lipid-Based Drug Delivery Systems for Diseases Managements

Douweh Leyla Gbian  1 , Abdelwahab Omri  1
Affiliations
Review

Lipid-Based Drug Delivery Systems for Diseases Managements

Douweh Leyla Gbian et al. Biomedicines. .

Abstract

Liposomes are tiny lipid-based vesicles composed of one or more lipid bilayers, which facilitate the encapsulation of hydrophilic, lipophilic, and amphiphilic biological active agents. The description of the physicochemical properties, formulation methods, characteristics, mechanisms of action, and large-scale manufacturing of liposomes as delivery systems are deeply discussed. The benefits, toxicity, and limitations of the use of liposomes in pharmacotherapeutics including in diagnostics, brain targeting, eye and cancer diseases, and in infections are provided. The experimental approaches that may reduce, or even bypass, the use of liposomal drug drawbacks is described. The application of liposomes in the treatment of numerous diseases is discussed.

Keywords: applications; characterization; drug delivery; liposomes.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Classification and composition of liposomes. Liposomes can be classified based on their size, their lamellarity, and their composition. The red dots represent hydrophobic drugs whereas the blue ones represent hydrophilic drugs.
Figure 2
Figure 2
Methods of liposomes preparation.
Figure 3
Figure 3
Mechanisms of liposomes uptake into cells. Liposomes can deliver their content into cells through various mechanisms including lipid exchange, surface interactions, fusion, endocytosis, and pinocytosis.
See this image and copyright information in PMC

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This research received no external funding.

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