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Review
. 2022 Dec:75:101718.
doi: 10.1016/j.trim.2022.101718. Epub 2022 Sep 17.

NLRP3 inflammasome: A potential therapeutic target to minimize renal ischemia/reperfusion injury during transplantation

Xiaochen Su  1 , Bin Liu  1 , Shangguo Wang  1 , Yuxiong Wang  1 , Zehua Zhang  1 , Honglan Zhou  2 , Faping Li  3
Affiliations
Review

NLRP3 inflammasome: A potential therapeutic target to minimize renal ischemia/reperfusion injury during transplantation

Xiaochen Su et al. Transpl Immunol. 2022 Dec.

Abstract

Renal transplantation is currently the best treatment option for patients with end-stage kidney disease. Ischemia/reperfusion injury (IRI), which is an inevitable event during renal transplantation, has a profound impact on the function of transplanted kidneys. It has been well demonstrated that innate immune system plays an important role in the process of renal IRI. As a critical component of innate immune system, Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has received great attention from scientific community over the past decade. The main function of NLRP3 inflammasome is mediating activation of caspase-1 and maturation of interleukin (IL)-1β and IL-18. In this review, we summarize the associated molecular signaling events about NLRP3 inflammasome in renal IRI, and highlight the possibility of targeting NLRP3 inflammasome to minimize renal IRI during transplantation.

Keywords: Caspase-1; Ischemia/reperfusion injury; NLRP3 inflammasome; Renal transplantation.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no competing interests.

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