Kappa opioids in rhesus monkeys. I. Diuresis, sedation, analgesia and discriminative stimulus effects
- PMID: 3612543
Kappa opioids in rhesus monkeys. I. Diuresis, sedation, analgesia and discriminative stimulus effects
Abstract
The effects of the kappa agonists bremazocine, ethylketazocine, tifluadom and U-50,488 were examined in rhesus monkeys with four experimental procedures: urinary output was measured in normally hydrated monkeys; muscle relaxation and stupor were observed; and the time it took monkeys to withdraw their tails from warm water was evaluated. Lastly, the kappa agonists were examined in monkeys trained to respond differentially in the presence or absence of ethylketazocine. For comparison, morphine and another kappa agonist, Mr 2033, were examined under some of the procedures. Kappa agonists produced dose-dependent increases in urine output whereas morphine did not. Morphine, as well as each of the kappa agonists examined, produced dose-dependent increases in tail-withdrawal latencies from both 50 and 55 degrees C water; analgesic doses of kappa agonists produced marked stupor and muscle relaxation. Kappa agonists produced ethylketazocine-appropriate responding in the drug discrimination procedure. Doses of kappa agonists that produced ethylketazocine-appropriate responding were similar to doses that increased urine output and smaller than doses that increased tail-withdrawal latencies. The opioid antagonist quadazocine (WIN 44,441) antagonized the effects of bremazocine, ethylketazocine, tifluadom and U-50,488.
Similar articles
-
Kappa opioids in rhesus monkeys. II. Analysis of the antagonistic actions of quadazocine and beta-funaltrexamine.J Pharmacol Exp Ther. 1987 Aug;242(2):421-7. J Pharmacol Exp Ther. 1987. PMID: 3302207
-
Differentiation between mu and kappa receptor-mediated effects in opioid drug discrimination: apparent pA2 analysis.J Pharmacol Exp Ther. 1987 Nov;243(2):591-7. J Pharmacol Exp Ther. 1987. PMID: 2824753
-
Classification of narcotics on the basis of their reinforcing, discriminative, and antagonist effects in rhesus monkeys.Fed Proc. 1982 Feb;41(2):221-7. Fed Proc. 1982. PMID: 7037459
-
Discriminative and analgesic effects of mu and kappa opioids: in vivo pA2 analysis.Psychopharmacol Ser. 1988;4:107-21. doi: 10.1007/978-3-642-73223-2_9. Psychopharmacol Ser. 1988. PMID: 2899316 Review.
-
Behavioral characterization of opioid mixed agonist-antagonists.Drug Alcohol Depend. 1987 Dec;20(4):303-15. doi: 10.1016/0376-8716(87)90004-4. Drug Alcohol Depend. 1987. PMID: 2831018 Review.
Cited by
-
Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics.Int J Mol Sci. 2022 Aug 25;23(17):9623. doi: 10.3390/ijms23179623. Int J Mol Sci. 2022. PMID: 36077029 Free PMC article.
-
Micro/kappa opioid interactions in rhesus monkeys: implications for analgesia and abuse liability.Exp Clin Psychopharmacol. 2008 Oct;16(5):386-99. doi: 10.1037/a0013088. Exp Clin Psychopharmacol. 2008. PMID: 18837635 Free PMC article.
-
Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeys.Neuropsychopharmacology. 2009 Aug;34(9):2088-96. doi: 10.1038/npp.2009.33. Epub 2009 Mar 11. Neuropsychopharmacology. 2009. PMID: 19279568 Free PMC article.
-
Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects.J Pain Res. 2018 Apr 11;11:735-741. doi: 10.2147/JPR.S152879. eCollection 2018. J Pain Res. 2018. PMID: 29692626 Free PMC article.
-
Trends in drug discrimination research analysed with a cross-indexed bibliography, 1984-1987.Psychopharmacology (Berl). 1989;98(1):1-19. doi: 10.1007/BF00442000. Psychopharmacology (Berl). 1989. PMID: 2498952 No abstract available.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
