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. 2022 Sep 19;21(1):88.
doi: 10.1186/s12944-022-01697-9.

Fat-to-muscle ratio as a predictor for dyslipidaemia in transitional-age youth

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Fat-to-muscle ratio as a predictor for dyslipidaemia in transitional-age youth

Jia-Xing Zhang et al. Lipids Health Dis. .

Abstract

Background: Although dyslipidaemia may have a crucial impact on cardiovascular health in adults, there is a lack of specific data in transitional-age youth. Therefore, this study attempted to evaluate the association of dyslipidaemia with fat-to-muscle ratio (FMR), and establish FMR thresholds for diagnosing dyslipidaemia in transitional-age youth.

Methods: One thousand six hundred sixty individuals aged 16 to 24 years from the baseline of a subcohort in the Northwest China Natural Population Cohort: Ningxia Project were analysed. Anthropometric characteristics were gauged by a bioelectrical impedance analyser, and dyslipidaemia components were measured using a Beckman AU480 chemistry analyser. Additionally, this study used logistic regression to estimate the risk of dyslipidaemia based on FMR quintiles, and calculate the gender-specific ideal cut-off values of dyslipidaemia and its components by the receiver operating characteristic (ROC) curve.

Results: Of the 1660 participants, aged 19.06 ± 1.14 years, 558 males and 1102 females. The prevalence of dyslipidaemia was 13.4% and was significantly associated with FMR quintiles among all participants (P < 0.05). The ideal values of FMR in diagnosing dyslipidaemia were 0.2224 for males and 0.4809 for females, while males had a higher AUC than females (0.7118 vs. 0.6656). Meanwhile, high FMR values were significantly associated with adverse outcomes of dyslipidaemia, hypercholesterolemia and hypertriglyceridaemia (P < 0.05).

Conclusions: The FMR was positively correlated with the prevalence of dyslipidaemia. The FMR can be used as an effective body composition index for diagnosing dyslipidaemia, especially in males, and preventive strategies should be initiated in transitional-age youth to decrease obesity-related dyslipidaemia.

Keywords: Dyslipidaemia; Fat-to-muscle ratio; Muscle; Transitional-age youth.

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Conflict of interest statement

The authors declare no competing interests.

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
An outline of the procedure for choosing the study population
Fig. 2
Fig. 2
The sex-specific FMR cut-off points and ROC curves for identifying dyslipidaemia and its components. (A) Males, dyslipidaemia; (B) Females, dyslipidaemia. (C) Males, hypercholesterolemia; (D) Females, hypercholesterolemia. (E) Males, hypertriglyceridaemia; (F) Females, hypertriglyceridaemia

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References

    1. Hruby A, Hu FB. The Epidemiology of Obesity: A Big Picture. Pharmacoeconomics. 2015;33:673–689. doi: 10.1007/s40273-014-0243-x. - DOI - PMC - PubMed
    1. Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism-Clinical and Experimental. 2019;92:6–10. doi: 10.1016/j.metabol.2018.09.005. - DOI - PubMed
    1. Kim YJ, Kwon EY, Kim JW, Lee Y, Ryu R, Yun J, Kim M, Choi MS. Intervention Study on the Efficacy and Safety of Platycodon grandiflorus Ethanol Extract in Overweight or Moderately Obese Adults: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2019;11(10):2445. - PMC - PubMed
    1. Raghuveer G. Lifetime cardiovascular risk of childhood obesity. Am J Clin Nutr. 2010;91:1514S–1519S. doi: 10.3945/ajcn.2010.28701D. - DOI - PubMed
    1. Mocnik M, Marcun Varda N. Cardiovascular Risk Factors in Children with Obesity, Preventive Diagnostics and Possible Interventions. Metabolites. 2021;11(8):551. - PMC - PubMed

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