Quantum dots in the biomedical world: A smart advanced nanocarrier for multiple venues application

doi:10.1002/ardp.202200299

Review

. 2022 Dec;355(12):e2200299.

doi: 10.1002/ardp.202200299. Epub 2022 Sep 4.

Quantum dots in the biomedical world: A smart advanced nanocarrier for multiple venues application

Siddharth Singh¹, Deepika Raina², Dinesh Rishipathak³, Kamesh R Babu⁴, Riya Khurana⁵, Yogesh Gupta⁶, Kartik Garg⁶, Farah Rehan⁷, Shraddha M Gupta¹

Affiliations

¹ Department of Pharmaceutical Sciences, School of Health Sciences and Technology, University of Petroleum and Energy Studies (UPES), Dehradun, Uttarakhand, India.
² School of Pharmacy, Graphic era hill University, Dehradun, Uttarakhand, India.
³ Department of Pharmaceutical Chemistry, MET's Institute of Pharmacy, Nashik, Maharashtra, India.
⁴ Department of Allied Health Sciences, School of Health Sciences and Technology, University of Petroleum and Energy Studies (UPES), Dehradun, Uttarakhand, India.
⁵ Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India.
⁶ Faculty of Pharmaceutical Sciences, PDM University, Bahadurgarh, Haryana, India.
⁷ Department of Pharmacy, Forman Christian College (A Chartered University), Lahore, Pakistan.

PMID: 36058643
DOI: 10.1002/ardp.202200299

Review

Quantum dots in the biomedical world: A smart advanced nanocarrier for multiple venues application

Siddharth Singh et al. Arch Pharm (Weinheim). 2022 Dec.

. 2022 Dec;355(12):e2200299.

doi: 10.1002/ardp.202200299. Epub 2022 Sep 4.

Authors

Siddharth Singh¹, Deepika Raina², Dinesh Rishipathak³, Kamesh R Babu⁴, Riya Khurana⁵, Yogesh Gupta⁶, Kartik Garg⁶, Farah Rehan⁷, Shraddha M Gupta¹

Affiliations

¹ Department of Pharmaceutical Sciences, School of Health Sciences and Technology, University of Petroleum and Energy Studies (UPES), Dehradun, Uttarakhand, India.
² School of Pharmacy, Graphic era hill University, Dehradun, Uttarakhand, India.
³ Department of Pharmaceutical Chemistry, MET's Institute of Pharmacy, Nashik, Maharashtra, India.
⁴ Department of Allied Health Sciences, School of Health Sciences and Technology, University of Petroleum and Energy Studies (UPES), Dehradun, Uttarakhand, India.
⁵ Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India.
⁶ Faculty of Pharmaceutical Sciences, PDM University, Bahadurgarh, Haryana, India.
⁷ Department of Pharmacy, Forman Christian College (A Chartered University), Lahore, Pakistan.

PMID: 36058643
DOI: 10.1002/ardp.202200299

Abstract

Quantum dots (QDs) are semiconducting nanoparticles having different optical and electrical properties when compared to larger particles. They exhibit photoluminescence when irradiated with ultraviolet light, which is due to the transition of an excited electron from the valence band to the conductance band followed by the return of the exciting electron back into the valence band. The size and material of QDs can affect their optical and other properties too. The QDs possess special attributes like high brightness, protection from photobleaching, photostability, color tunability, low toxicity, low production cost, a multiplexing limit, and a high surface-to-volume proportion, which make them a promising tool for biomedical applications. Here, in this study, we summarize the utilization of QDs in different applications including bioimaging, diagnostics, immunostaining, single-cell analysis, drug delivery, and protein detection. Moreover, we discuss the advantages and challenges of using QDs in biomedical applications when compared with other conventional tools.

Keywords: biosensors; cell and tissue imaging; drug delivery; protein detection; quantum dots.

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References

REFERENCES

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1. F. Erogbogbo, C.-A. Tien, C.-W. Chang, K.-T. Yong, W.-C. Law, H. Ding, I. Roy, M. T. Swihart, P. N. Prasad, Bioconjugate Chem. 2011, 22, 1081.
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1. S. Chinnathambi, S. Chen, S. Ganesan, N. Hanagata, Adv. Healthcare Mater. 2014, 3, 10.

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[1] R. D. Singh, R. Shandilya, A. Bhargava, R. Kumar, R. Tiwari, K. Chaudhury, R. K. Srivastava, I. Y. Goryacheva, P. K. Mishra, Front. Genet. 2018, 9, 616.

[2] R. D. Singh, R. Shandilya, A. Bhargava, R. Kumar, R. Tiwari, K. Chaudhury, R. K. Srivastava, I. Y. Goryacheva, P. K. Mishra, Front. Genet. 2018, 9, 616.

[3] F. Erogbogbo, C.-A. Tien, C.-W. Chang, K.-T. Yong, W.-C. Law, H. Ding, I. Roy, M. T. Swihart, P. N. Prasad, Bioconjugate Chem. 2011, 22, 1081.

[4] F. Erogbogbo, C.-A. Tien, C.-W. Chang, K.-T. Yong, W.-C. Law, H. Ding, I. Roy, M. T. Swihart, P. N. Prasad, Bioconjugate Chem. 2011, 22, 1081.

[5] Z. Jin, N. Hildebrandt, Trends Biotechnol. 2012, 30, 394.

[6] Z. Jin, N. Hildebrandt, Trends Biotechnol. 2012, 30, 394.

[7] S. Şahin, C. Ünlü, L. Trabzon, Emerg. Mater. 2021, 4, 187.

[8] S. Şahin, C. Ünlü, L. Trabzon, Emerg. Mater. 2021, 4, 187.

[9] S. Chinnathambi, S. Chen, S. Ganesan, N. Hanagata, Adv. Healthcare Mater. 2014, 3, 10.

[10] S. Chinnathambi, S. Chen, S. Ganesan, N. Hanagata, Adv. Healthcare Mater. 2014, 3, 10.

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Quantum dots in the biomedical world: A smart advanced nanocarrier for multiple venues application

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Quantum dots in the biomedical world: A smart advanced nanocarrier for multiple venues application

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Abstract

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