"One Shot" Sample Evaluation of 22G, 22G upgraded, 21G and 19G needle for Endobronchial Ultrasound-EBUS-TBNA

doi:10.7150/jca.74022

. 2022 Jul 18;13(10):2982-2987.

doi: 10.7150/jca.74022. eCollection 2022.

"One Shot" Sample Evaluation of 22G, 22G upgraded, 21G and 19G needle for Endobronchial Ultrasound-EBUS-TBNA

Rena Oikonomidou¹, Dimitris Petridis², Petros Alexidis³, Dimitris Matthaios⁴, Ioannis Boukovinas⁵, Eleni Isidora Perdikouri⁶, Sofie Baka⁷, Wolfgang Hohenforst-Schmidt⁸, Haidong Huang⁹, Chong Bai⁹, Bojan Zaric¹⁰, Lutz Freitag¹¹, Nikolaos Courcoutsakis¹², Marios Anemoulis¹³, Christoforos Kosmidis¹⁴, Christoforos Foroulis¹⁵, Savas Petanidis¹⁶, Vasilis Papadopoulos¹⁷, Aris Ioannidis¹⁸, Paul Zarogoulidis¹⁹

Affiliations

¹ Health center Evosmos, Thessaloniki, Greece.
² Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece.
³ Radiotherapy Department, ``G. Papageorgiou`` University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
⁴ Oncology Department, General Hospital of Rhodes, Rhodes, Greece.
⁵ Oncology Department, ``Bioclinic`` Private Hospital, Thessaloniki, Greece.
⁶ Oncology Department, General Hospital of Volos, Greece.
⁷ Oncology Department, ``Interbalkan`` European Medical Center, Thessaloniki, Greece.
⁸ Sana Clinic Group Franken, Department of Cardiology / Pulmonology / Intensive Care / Nephrology, ''Hof'' Clinics, University of Erlangen, Hof, Germany.
⁹ Department of Respiratory & Critical Care Medicine, Changhai Hospital, the Second Military Medical University, Shanghai, China.
¹⁰ Faculty of Medicine, University of Novi Sad, Institute for Pulmonary Diseases of Vojvodina, Novi Sad, Serbia.
¹¹ Department of Pulmonology, University Hospital Zurich, Rämistrasse 100, 8091, Zurich Switzerland.
¹² Radiology Department, Democritus University of Thrace, Alexandroupolis, Greece.
¹³ Surgery Department, General Clinic Euromedica, Thessaloniki, Greece.
¹⁴ 3rd Department of Surgery, ``AHEPA`` University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece.
¹⁵ Thoracic Surgery Department, ``AHEPA`` University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
¹⁶ Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece.
¹⁷ Oncology Department, University General Hospital of Thessaly, Thessaly, Greece.
¹⁸ Surgery Department, Genesis Private Clinic, Thessaloniki, Greece.
¹⁹ Pulmonary Oncology Department, ``Bioclinic`` Private Hospital, Thessaloniki, Greece.

PMID: 36046659
PMCID: PMC9414030
DOI: 10.7150/jca.74022

"One Shot" Sample Evaluation of 22G, 22G upgraded, 21G and 19G needle for Endobronchial Ultrasound-EBUS-TBNA

Rena Oikonomidou et al. J Cancer. 2022.

. 2022 Jul 18;13(10):2982-2987.

doi: 10.7150/jca.74022. eCollection 2022.

Authors

Affiliations

¹ Health center Evosmos, Thessaloniki, Greece.
² Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece.
³ Radiotherapy Department, ``G. Papageorgiou`` University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
⁴ Oncology Department, General Hospital of Rhodes, Rhodes, Greece.
⁵ Oncology Department, ``Bioclinic`` Private Hospital, Thessaloniki, Greece.
⁶ Oncology Department, General Hospital of Volos, Greece.
⁷ Oncology Department, ``Interbalkan`` European Medical Center, Thessaloniki, Greece.
⁸ Sana Clinic Group Franken, Department of Cardiology / Pulmonology / Intensive Care / Nephrology, ''Hof'' Clinics, University of Erlangen, Hof, Germany.
⁹ Department of Respiratory & Critical Care Medicine, Changhai Hospital, the Second Military Medical University, Shanghai, China.
¹⁰ Faculty of Medicine, University of Novi Sad, Institute for Pulmonary Diseases of Vojvodina, Novi Sad, Serbia.
¹¹ Department of Pulmonology, University Hospital Zurich, Rämistrasse 100, 8091, Zurich Switzerland.
¹² Radiology Department, Democritus University of Thrace, Alexandroupolis, Greece.
¹³ Surgery Department, General Clinic Euromedica, Thessaloniki, Greece.
¹⁴ 3rd Department of Surgery, ``AHEPA`` University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece.
¹⁵ Thoracic Surgery Department, ``AHEPA`` University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
¹⁶ Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece.
¹⁷ Oncology Department, University General Hospital of Thessaly, Thessaly, Greece.
¹⁸ Surgery Department, Genesis Private Clinic, Thessaloniki, Greece.
¹⁹ Pulmonary Oncology Department, ``Bioclinic`` Private Hospital, Thessaloniki, Greece.

PMID: 36046659
PMCID: PMC9414030
DOI: 10.7150/jca.74022

Abstract

Background: There are still diagnostic issues with lung cancer and mediastinum lymphadenopathy. Endobronchial ultrasound (EBUS) is a state of the art equipment for the diagnosis of lymphadenopathy and central lesions. Objective: To investigate the sample size with one pass. Patients and Methods: 248 Stage IV patients were included in our study. All patients had a CT of the thorax with either lymphadenopathy or lyphadenopathy plus pulmonary lesions. Patients had a biopsy with endobronchial ultrasound with 22G Mediglope, 22G Mediglope Sonotip, 21G Olympus and 19G Olympus needle. We collected information regarding the cancer type, cell block, tissue, age, sex, lesion size and needle type. Results: The cancer type diagnosis was associated with the needle diameter. The number of cell-blocks were associated with the lesion size and needle diameter. Slices from the tissue and cell-blocks were again associated with the lesion size and needle diameter. Conclusion: One pass is enough for cancer diagnosis, however; careful selection has to be made among patients regarding the needle diameter. In the case of lymphoma suspicion we should use 19G needle.

Keywords: 19G needle; 21G needle; 22G needle; EBUS-TBNA; biopsy; bronchoscopy; lung cancer; lymphnodes.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

**Figure 2**
Left: 19G Olympus^® and Right: the sample which is tissue.

**Figure 3**
Left: 22G Mediglobe^®, Middle: 22G Mediglobe^® upgraded needle and Right: the sample which is like a ``pus`` material.

**Figure 4**
Summary statistics, box plot and size frequency distribution of age and number of slices of patients.

See this image and copyright information in PMC

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References

1. Hu H, Li C, Lv T, Li H, Hu Y, Shen Q. et al. Contrast-enhanced computed tomography prior to percutaneous transthoracic needle biopsy reduces the incidence of hemorrhage. Annals of translational medicine. 2021;9:288. - PMC - PubMed
1. Huang Z, Huang H, Ning Y, Han J, Shen Y, Shi H. et al. Radial probe endobronchial ultrasound assisted conventional transbronchial needle aspiration in the diagnosis of solitary peribronchial pulmonary lesion located in the segmental bronchi. Journal of Cancer. 2019;10:634–42. - PMC - PubMed
1. Zaric B, Stojsic V, Carapic V, Kovacevic T, Stojanovic G, Panjkovic M. et al. Radial Endobronchial Ultrasound (EBUS) Guided Suction Catheter-Biopsy in Histological Diagnosis of Peripheral Pulmonary Lesions. Journal of Cancer. 2016;7:7–13. - PMC - PubMed
1. Haidong H, Yunye N, Wei Z, Zarogoulidis P, Hohenforst-Schmidt W, Man YG. et al. Multiple guided technologies based on radial probe endobronchial ultrasound for the diagnosis of solitary peripheral pulmonary lesions: a single-center study. Journal of Cancer. 2017;8:3514–21. - PMC - PubMed
1. Zaric B, Stojsic V, Sarcev T, Stojanovic G, Carapic V, Perin B. et al. Advanced bronchoscopic techniques in diagnosis and staging of lung cancer. Journal of thoracic disease. 2013;5(Suppl 4):S359–70. - PMC - PubMed

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[1] Hu H, Li C, Lv T, Li H, Hu Y, Shen Q. et al. Contrast-enhanced computed tomography prior to percutaneous transthoracic needle biopsy reduces the incidence of hemorrhage. Annals of translational medicine. 2021;9:288. - PMC - PubMed

[2] Hu H, Li C, Lv T, Li H, Hu Y, Shen Q. et al. Contrast-enhanced computed tomography prior to percutaneous transthoracic needle biopsy reduces the incidence of hemorrhage. Annals of translational medicine. 2021;9:288. - PMC - PubMed

[3] Huang Z, Huang H, Ning Y, Han J, Shen Y, Shi H. et al. Radial probe endobronchial ultrasound assisted conventional transbronchial needle aspiration in the diagnosis of solitary peribronchial pulmonary lesion located in the segmental bronchi. Journal of Cancer. 2019;10:634–42. - PMC - PubMed

[4] Huang Z, Huang H, Ning Y, Han J, Shen Y, Shi H. et al. Radial probe endobronchial ultrasound assisted conventional transbronchial needle aspiration in the diagnosis of solitary peribronchial pulmonary lesion located in the segmental bronchi. Journal of Cancer. 2019;10:634–42. - PMC - PubMed

[5] Zaric B, Stojsic V, Carapic V, Kovacevic T, Stojanovic G, Panjkovic M. et al. Radial Endobronchial Ultrasound (EBUS) Guided Suction Catheter-Biopsy in Histological Diagnosis of Peripheral Pulmonary Lesions. Journal of Cancer. 2016;7:7–13. - PMC - PubMed

[6] Zaric B, Stojsic V, Carapic V, Kovacevic T, Stojanovic G, Panjkovic M. et al. Radial Endobronchial Ultrasound (EBUS) Guided Suction Catheter-Biopsy in Histological Diagnosis of Peripheral Pulmonary Lesions. Journal of Cancer. 2016;7:7–13. - PMC - PubMed

[7] Haidong H, Yunye N, Wei Z, Zarogoulidis P, Hohenforst-Schmidt W, Man YG. et al. Multiple guided technologies based on radial probe endobronchial ultrasound for the diagnosis of solitary peripheral pulmonary lesions: a single-center study. Journal of Cancer. 2017;8:3514–21. - PMC - PubMed

[8] Haidong H, Yunye N, Wei Z, Zarogoulidis P, Hohenforst-Schmidt W, Man YG. et al. Multiple guided technologies based on radial probe endobronchial ultrasound for the diagnosis of solitary peripheral pulmonary lesions: a single-center study. Journal of Cancer. 2017;8:3514–21. - PMC - PubMed

[9] Zaric B, Stojsic V, Sarcev T, Stojanovic G, Carapic V, Perin B. et al. Advanced bronchoscopic techniques in diagnosis and staging of lung cancer. Journal of thoracic disease. 2013;5(Suppl 4):S359–70. - PMC - PubMed

[10] Zaric B, Stojsic V, Sarcev T, Stojanovic G, Carapic V, Perin B. et al. Advanced bronchoscopic techniques in diagnosis and staging of lung cancer. Journal of thoracic disease. 2013;5(Suppl 4):S359–70. - PMC - PubMed

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"One Shot" Sample Evaluation of 22G, 22G upgraded, 21G and 19G needle for Endobronchial Ultrasound-EBUS-TBNA

Affiliations

"One Shot" Sample Evaluation of 22G, 22G upgraded, 21G and 19G needle for Endobronchial Ultrasound-EBUS-TBNA

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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Cited by

References

LinkOut - more resources

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