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Review
. 2022 Oct;100(10):1373-1386.
doi: 10.1007/s00109-022-02247-7. Epub 2022 Aug 30.

Histone modification in podocyte injury of diabetic nephropathy

Simeng Wang  1 , Xinyu Zhang  1 , Qinglian Wang  2   3 , Rong Wang  4   5
Affiliations
Review

Histone modification in podocyte injury of diabetic nephropathy

Simeng Wang et al. J Mol Med (Berl). 2022 Oct.

Abstract

Diabetic nephropathy (DN), an important complication of diabetic microvascular disease, is one of the leading causes of end-stage renal disease (ESRD), which brings heavy burdens to the whole society. Podocytes are terminally differentiated glomerular cells, which act as a pivotal component of glomerular filtration barrier. When podocytes are injured, glomerular filtration barrier is damaged, and proteinuria would occur. Dysfunction of podocytes contributes to DN. And degrees of podocyte injury influence prognosis of DN. Growing evidences have shown that epigenetics does a lot in the evolvement of podocyte injury. Epigenetics includes DNA methylation, histone modification, and non-coding RNA. Among them, histone modification plays an indelible role. Histone modification includes histone methylation, histone acetylation, and other modifications such as histone phosphorylation, histone ubiquitination, histone ADP-ribosylation, histone crotonylation, and histone β-hydroxybutyrylation. It can affect chromatin structure and regulate gene transcription to exert its function. This review is to summarize documents about pathogenesis of podocyte injury, most importantly, histone modification of podocyte injury in DN recently to provide new ideas for further molecular research, diagnosis, and treatment.

Keywords: Diabetic nephropathy; Histone acetylation; Histone methylation; Histone modification; Podocyte.

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References

    1. Qi C, Mao X, Zhang Z, Wu H (2017) Classification and differential diagnosis of diabetic nephropathy. J Diabetes Res 2017:8637138 - PubMed - PMC
    1. Nagata M (2016) Podocyte injury and its consequences. Kidney Int 89(6):1221–1230 - PubMed - DOI
    1. White KE, Bilous RW (2004) Structural alterations to the podocyte are related to proteinuria in type 2 diabetic patients. Nephrol Dial Transplant 19(6):1437–1440 - PubMed - DOI
    1. Lan J, Lepikhov K, Giehr P, Walter J (2017) Histone and DNA methylation control by H3 serine 10/threonine 11 phosphorylation in the mouse zygote. Epigenetics Chromatin 10:5 - PubMed - PMC - DOI
    1. Nathan DM (2014) The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview. Diabetes Care 37(1):9–16 - PubMed - DOI

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