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Review
. 2023:1409:51-81.
doi: 10.1007/5584_2022_731.

Pathophysiology of Spinal Cord Injury and Tissue Engineering Approach for Its Neuronal Regeneration: Current Status and Future Prospects

Leena R Chaudhari  1 , Akshay A Kawale  1 , Sangeeta S Desai  2 , Shivaji B Kashte  1 , Meghnad G Joshi  3   4
Affiliations
Review

Pathophysiology of Spinal Cord Injury and Tissue Engineering Approach for Its Neuronal Regeneration: Current Status and Future Prospects

Leena R Chaudhari et al. Adv Exp Med Biol. 2023.

Abstract

A spinal cord injury (SCI) is a very debilitating condition causing loss of sensory and motor function as well as multiple organ failures. Current therapeutic options like surgery and pharmacotherapy show positive results but are incapable of providing a complete cure for chronic SCI symptoms. Tissue engineering, including neuroprotective or growth factors, stem cells, and biomaterial scaffolds, grabs attention because of their potential for regeneration and ability to bridge the gap in the injured spinal cord (SC). Preclinical studies with tissue engineering showed functional recovery and neurorestorative effects. Few clinical trials show the safety and efficacy of the tissue engineering approach. However, more studies should be carried out for potential treatment modalities. In this review, we summarize the pathophysiology of SCI and its current treatment modalities, including surgical, pharmacological, and tissue engineering approaches following SCI in preclinical and clinical phases.

Keywords: Neuroprotection; Neuroregeneration; Scaffolds; Spinal cord injury; Stem cells; Tissue engineering.

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