The miR393-Target Module Regulates Plant Development and Responses to Biotic and Abiotic Stresses

doi:10.3390/ijms23169477

Review

. 2022 Aug 22;23(16):9477.

doi: 10.3390/ijms23169477.

The miR393-Target Module Regulates Plant Development and Responses to Biotic and Abiotic Stresses

Jinjin Jiang¹, Haotian Zhu¹, Na Li¹, Jacqueline Batley², Youping Wang^{1

3}

Affiliations

¹ Jiangsu Provincial Key Laboratory of Crop Genetics and Physiology, Yangzhou University, Yangzhou 225009, China.
² School of Biological Sciences, University of Western Australia, Perth, WA 6009, Australia.
³ Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.

PMID: 36012740
PMCID: PMC9409142
DOI: 10.3390/ijms23169477

Review

The miR393-Target Module Regulates Plant Development and Responses to Biotic and Abiotic Stresses

Jinjin Jiang et al. Int J Mol Sci. 2022.

. 2022 Aug 22;23(16):9477.

doi: 10.3390/ijms23169477.

Authors

Jinjin Jiang¹, Haotian Zhu¹, Na Li¹, Jacqueline Batley², Youping Wang^{1

3}

Affiliations

¹ Jiangsu Provincial Key Laboratory of Crop Genetics and Physiology, Yangzhou University, Yangzhou 225009, China.
² School of Biological Sciences, University of Western Australia, Perth, WA 6009, Australia.
³ Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.

PMID: 36012740
PMCID: PMC9409142
DOI: 10.3390/ijms23169477

Abstract

MicroRNAs (miRNAs), a class of endogenous small RNAs, are broadly involved in plant development, morphogenesis and responses to various environmental stresses, through manipulating the cleavage, translational expression, or DNA methylation of target mRNAs. miR393 is a conserved miRNA family present in many plants, which mainly targets genes encoding the transport inhibitor response1 (TIR1)/auxin signaling F-box (AFB) auxin receptors, and thus greatly affects the auxin signal perception, Aux/IAA degradation, and related gene expression. This review introduces the advances made on the miR393/target module regulating plant development and the plant's responses to biotic and abiotic stresses. This module is valuable for genetic manipulation of optimized conditions for crop growth and development and would also be helpful in improving crop yield through molecular breeding.

Keywords: auxin; miR393; plant development; stress response; target gene.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
The conserved sequence similarity of miR393 members in different plants. (A) Phylogenetic relationships of pre-miR393s; (B) sequence similarity of mature miR393s. Aly, *Arabidopsis lyrata*; Ata, *Aegilops tauschii*; Ath, *Arabidopsis thaliana*; Bdi, *Brachypodium distachyon*; Bna, *Brassica napus*; Cas, *Camelina sativa*; Cme, *Cucumis melo*; Csa, *Cucumis sativus*; Csi, *Camellia sinensis*; Ghr, *Gossypium hirsutum*; Gma, *Glycine max*; Hvu, *Hordeum vulgare*; Lus, *Linum usitatissimum*; Mes, *Manihot esculenta*; Mtr, *Medicago truncatula*; Osa, *Oryza sativa*; Rco, *Ricinus communis*; Sbi, *Sorghum bicolor*; Stu, *Solanum tuberosum*; Zma, *Zea mays*; Pvi, *Panicum virgatum*.

**Figure 2**
Phylogeny and structures of functionally characterized TIR1/AFBs in plants. Ah, *Arachis hypogaea*; At, *Arabidopsis thaliana*; As, *Agrostis stolonifera*; Cm, *Cucumis melo*; Cs: *Cucumis sativus*; Dl: *Dimocarpus longan*; Gm, *Glycine max*; Hv, *Hordeum* *vulgare*; Md, *Malus × domestica*; Os, *Oryza sativa*; Pv, *Panicum virgatum*; Zm, *Zea mays*.

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References

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1. Song X.W., Li Y., Cao X.F., Qi Y.J. MicroRNAs and their regulatory roles in plant-environment interactions. Annu. Rev. Plant Biol. 2019;70:489–525. doi: 10.1146/annurev-arplant-050718-100334. - DOI - PubMed
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[1] Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75:843–854. doi: 10.1016/0092-8674(93)90529-Y. - DOI - PubMed

[2] Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75:843–854. doi: 10.1016/0092-8674(93)90529-Y. - DOI - PubMed

[3] D’Ario M., Griffiths-Jones S., Kim M. Small RNAs: Big impact on plant development. Trends Plant Sci. 2017;22:1056–1068. doi: 10.1016/j.tplants.2017.09.009. - DOI - PubMed

[4] D’Ario M., Griffiths-Jones S., Kim M. Small RNAs: Big impact on plant development. Trends Plant Sci. 2017;22:1056–1068. doi: 10.1016/j.tplants.2017.09.009. - DOI - PubMed

[5] Xie M., Zhang S., Yu B. microRNA biogenesis, degradation and activity in plants. Cell. Mol. Life Sci. 2015;72:87–99. doi: 10.1007/s00018-014-1728-7. - DOI - PMC - PubMed

[6] Xie M., Zhang S., Yu B. microRNA biogenesis, degradation and activity in plants. Cell. Mol. Life Sci. 2015;72:87–99. doi: 10.1007/s00018-014-1728-7. - DOI - PMC - PubMed

[7] Song X.W., Li Y., Cao X.F., Qi Y.J. MicroRNAs and their regulatory roles in plant-environment interactions. Annu. Rev. Plant Biol. 2019;70:489–525. doi: 10.1146/annurev-arplant-050718-100334. - DOI - PubMed

[8] Song X.W., Li Y., Cao X.F., Qi Y.J. MicroRNAs and their regulatory roles in plant-environment interactions. Annu. Rev. Plant Biol. 2019;70:489–525. doi: 10.1146/annurev-arplant-050718-100334. - DOI - PubMed

[9] Khraiwesh B., Arif M.A., Seumel G.I., Ossowski S., Weigel D., Reski R., Frank W. Transcriptional control of gene expression by microRNAs. Cell. 2010;140:111–122. doi: 10.1016/j.cell.2009.12.023. - DOI - PubMed

[10] Khraiwesh B., Arif M.A., Seumel G.I., Ossowski S., Weigel D., Reski R., Frank W. Transcriptional control of gene expression by microRNAs. Cell. 2010;140:111–122. doi: 10.1016/j.cell.2009.12.023. - DOI - PubMed

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The miR393-Target Module Regulates Plant Development and Responses to Biotic and Abiotic Stresses

Affiliations

The miR393-Target Module Regulates Plant Development and Responses to Biotic and Abiotic Stresses

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