The integrated comprehension of lncRNA HOXA-AS3 implication on human diseases
- PMID: 35986859
- PMCID: PMC9568475
- DOI: 10.1007/s12094-022-02920-w
The integrated comprehension of lncRNA HOXA-AS3 implication on human diseases
Abstract
Long non-coding RNA (lncRNA) is a non-protein-coding RNA with a length of more than 200 nucleotides. Studies have shown that lncRNAs have vital impacts on various pathological processes and participate in the development of human diseases, usually through acting as competing endogenous RNAs to modulate miRNA expression and biological functions. lncRNA HOXA Cluster Antisense RNA 3 (HOXA-AS3) was a newly discovered lncRNA and has been demonstrated to be abnormally expressed in many diseases. Moreover, HOXA-AS3 expression was closely correlated with the clinicopathologic characteristics in cancer patients. In addition, HOXA-AS3 exhibited significant properties in regulating several biological processes, including cell proliferation, invasion, and migration. Furthermore, HOXA-AS3 has provided promising values in the diagnosis, prognosis, and therapeutic strategies of several diseases such as liver cancer, glioma, lung cancer, oral cancer, gastric cancer, and even atherosclerosis. In this review, we discuss the abnormal expression of HOXA-AS3 in several human disorders and some pathobiological processes and its clinical characteristics, followed by a summary of HOXA-AS3 functions, regulatory mechanisms, and clinical application potential.
Keywords: Clinical applications; HOXA-AS3; Long non-coding RNAs; Mechanism; Tumor promoter.
© 2022. The Author(s).
Conflict of interest statement
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Figures
Similar articles
-
LncRNA HOXA-AS3 promotes cell proliferation and invasion via targeting miR-218-5p/FOXP1 axis in osteosarcoma.Sci Rep. 2024 Jul 17;14(1):16581. doi: 10.1038/s41598-024-67596-4. Sci Rep. 2024. PMID: 39019995 Free PMC article.
-
LncRNA HOXA-AS3 promotes the malignancy of glioblastoma through regulating miR-455-5p/USP3 axis.J Cell Mol Med. 2020 Oct;24(20):11755-11767. doi: 10.1111/jcmm.15788. Epub 2020 Sep 11. J Cell Mol Med. 2020. PMID: 32918360 Free PMC article.
-
Long non-coding HOXA-AS3 contributes to osteosarcoma progression through the miR-1286/TEAD1 axis.J Orthop Surg Res. 2023 Sep 27;18(1):730. doi: 10.1186/s13018-023-04214-5. J Orthop Surg Res. 2023. PMID: 37752588 Free PMC article.
-
Tumour-regulatory role of long non-coding RNA HOXA-AS3.Prog Biophys Mol Biol. 2024 Jul;189:13-25. doi: 10.1016/j.pbiomolbio.2024.04.003. Epub 2024 Apr 7. Prog Biophys Mol Biol. 2024. PMID: 38593905 Review.
-
LncRNA HOXA-AS2 and its molecular mechanisms in human cancer.Clin Chim Acta. 2018 Oct;485:229-233. doi: 10.1016/j.cca.2018.07.004. Epub 2018 Jul 4. Clin Chim Acta. 2018. PMID: 29981289 Review.
Cited by
-
A concise review of the regulatory, diagnostic, and prognostic implications of HOXB-AS3 in tumors.J Cancer. 2024 Jan 1;15(3):714-728. doi: 10.7150/jca.91033. eCollection 2024. J Cancer. 2024. PMID: 38213732 Free PMC article. Review.
-
LncRNA HOXA-AS3 promotes cell proliferation and invasion via targeting miR-218-5p/FOXP1 axis in osteosarcoma.Sci Rep. 2024 Jul 17;14(1):16581. doi: 10.1038/s41598-024-67596-4. Sci Rep. 2024. PMID: 39019995 Free PMC article.
-
Hi-BDiSCO: folding 3D mesoscale genome structures from Hi-C data using brownian dynamics.Nucleic Acids Res. 2024 Jan 25;52(2):583-599. doi: 10.1093/nar/gkad1121. Nucleic Acids Res. 2024. PMID: 38015443 Free PMC article.
-
Heterogeneous Transcriptional Landscapes in Human Sporadic Parathyroid Gland Tumors.Int J Mol Sci. 2024 Oct 7;25(19):10782. doi: 10.3390/ijms251910782. Int J Mol Sci. 2024. PMID: 39409111 Free PMC article.
-
Methylation-Regulated Long Non-Coding RNA Expression in Ulcerative Colitis.Int J Mol Sci. 2023 Jun 22;24(13):10500. doi: 10.3390/ijms241310500. Int J Mol Sci. 2023. PMID: 37445676 Free PMC article.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical