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Review
. 2022 Jul;26(7):617-631.
doi: 10.1080/14728222.2022.2114897. Epub 2022 Aug 30.

The role of immune response in the pathogenesis of idiopathic pulmonary fibrosis: far beyond the Th1/Th2 imbalance

Paolo Spagnolo  1 , Roberto Tonelli  2   3   4 , Anna Valeria Samarelli  2   3 , Gioele Castelli  1 , Elisabetta Cocconcelli  1 , Simone Petrarulo  1 , Stefania Cerri  2   3 , Nicol Bernardinello  1 , Enrico Clini  2   3 , Marina Saetta  1 , Elisabetta Balestro  1
Affiliations
Review

The role of immune response in the pathogenesis of idiopathic pulmonary fibrosis: far beyond the Th1/Th2 imbalance

Paolo Spagnolo et al. Expert Opin Ther Targets. 2022 Jul.

Abstract

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic disease of unknown origin characterized by progressive scarring of the lung leading to irreversible loss of function. Despite the availability of two drugs that are able to slow down disease progression, IPF remains a deadly disease. The pathogenesis of IPF is poorly understood, but a dysregulated wound healing response following recurrent alveolar epithelial injury is thought to be crucial.

Areas covered: In the last few years, the role of the immune system in IPF pathobiology has been reconsidered; indeed, recent data suggest that a dysfunctional immune system may promote and unfavorable interplay with pro-fibrotic pathways thus acting as a cofactor in disease development and progression. In this article, we review and critically discuss the role of T cells in the pathogenesis and progression of IPF in the attempt to highlight ways in which further research in this area may enable the development of targeted immunomodulatory therapies for this dreadful disease.

Expert opinion: A better understanding of T cell interactions has the potential to facilitate the development of immune modulators targeting multiple T cell-mediated pathways, thus halting disease initiation and progression.

Keywords: Idiopathic pulmonary fibrosis; Th1; Th2; immune system; interstitial lung disease; pathogenesis.

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