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Review
. 2022 Nov;35(6):1640-1649.
doi: 10.1007/s13577-022-00768-4. Epub 2022 Aug 15.

The role of lincRNA-p21 in regulating the biology of cancer cells

Yan Huang #  1 , Qian Yi #  2   3 , Jianguo Feng  4 , Wei Xie  5 , Wei Sun  6 , Weichao Sun  7   8
Affiliations
Review

The role of lincRNA-p21 in regulating the biology of cancer cells

Yan Huang et al. Hum Cell. 2022 Nov.

Abstract

Long non-coding RNAs (lncRNAs) are a type of multifunctional endogenous RNA transcript. The dysregulation of lncRNAs is considered to play a role in the initiation and progression of cancer. One such lncRNA, long intergenic non-coding RNA-p21 (lincRNA-p21), was identified in 2010 as a regulator in the p53 pathway and is gradually being identified to play crucial roles in diverse cellular processes. In this review, we have summarised the diverse regulatory functions of lincRNA-p21. For example, lincRNA-p21 has been reported to function as a protein decoy, act as a competitive endogenous RNA, regulate the transcription, regulate the translation processes and exist in the secreted exosomes. Furthermore, we highlight the emerging roles of lincRNA-p21 in cancer cell regulation. Various types of cancers, including colorectal carcinoma, hepatocellular carcinoma and non-small cell lung carcinoma, aberrantly express lincRNA-p21. However, the current understanding of the roles of lincRNA-p21 in cancer remains limited. Therefore, considering its potential as a valuable therapeutic target or biomarker for cancer, more research should be conducted to understand the role of lincRNA-p21 in cancer and other diseases.

Keywords: Apoptosis; HIF-1α; LincRNA-p21; Proliferation; Tumorigenesis; p53 pathway.

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References

    1. Kopp F, Mendell JT. Functional classification and experimental dissection of long noncoding RNAs. Cell. 2018;172(3):393–407. - PubMed - PMC - DOI
    1. Quinn JJ, Chang HY. Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 2016;17(1):47–62. - PubMed - DOI
    1. Ransohoff JD, Wei Y, Khavari PA. The functions and unique features of long intergenic non-coding RNA. Nat Rev Mol Cell Biol. 2018;19(3):143–57. - PubMed - DOI
    1. Huarte M, et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell. 2010;142(3):409–19. - PubMed - PMC - DOI
    1. Chillon I, Pyle AM. Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function. Nucleic Acids Res. 2016;44(19):9462–71. - PubMed - PMC

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