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Review
. 2022 Aug 1:16:100377.
doi: 10.1016/j.mtbio.2022.100377. eCollection 2022 Dec.

Stem cell membrane-camouflaged targeted delivery system in tumor

Weiyue Zhang  1 , Xin Huang  2
Affiliations
Review

Stem cell membrane-camouflaged targeted delivery system in tumor

Weiyue Zhang et al. Mater Today Bio. .

Abstract

Cell membrane-coated nanoparticles (NPs) have attracted growing attention in the field of targeted delivery strategies, which successfully combine the advantages and properties of both cell membranes and synthetic NPs. Stem cell-based delivery systems have the innate targeting capability to tumor tissues, but inappropriate stem cells might promote tumor growth after being injected into the body. Accordingly, it is urgent to explore novel drug delivery systems that might combine the advantages of stem cells and eliminate the possible risks. This review aimed to investigate the stem cell membrane-camouflaged targeted delivery system in tumors. We discussed the underlying mechanisms of stem cell homing to target tumors. Then, the common membrane modification methods well as preparation methods of stem cell membrane coated NPs were concluded. NPs coating the stem cell membranes could obtain the tumor targeting ability, enhanced biocompatibility, and effective drug loading. Furthermore, we investigated the potential clinical applications of mesenchymal stem cells (MSCs) and induced pluripotent stem (iPS) cells membrane-camouflaged targeted delivery systems for anti-tumor therapies, such as chemotherapy, photodynamic therapy, magnetic hyperthermia therapy and imaging, CRISPR-Cas9 gene therapy, and synergistic therapy. Taken together, stem cell membrane-coated NPs hold the tremendous prospect for biomedical applications in tumor therapy.

Keywords: Membrane coated nanoparticles; Stem cell; Stem cell homing; Tumor targeting therapy.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Schematic illustration of stem cell homing and the stem cell membrane-camouflaged targeted delivery system in tumors.
Fig. 2
Fig. 2
Three common methods to modify stem cell membranes [16]. Adapted from Wang et al. (2021). Reprinted with permission from M. Wang, Y. Xin, H. Cao, W. Li, Y. Hua, T.J. Webster, C. Zhang, W. Tang, Z. Liu, Recent advances in mesenchymal stem cell membrane-coated nanoparticles for enhanced drug delivery, Biomater. Sci. 9 (2021) 1088-1103. Copyright 2021 Royal Society of Chemistry.
Fig. 3
Fig. 3
Common preparation methods of stem cell membrane coating nanotechnology: (a) physical extrusion method, (b) sonication method, and (c) microfluidic system with electroporation device [16]. Adapted from Wang et al. (2021). Reprinted with permission from M. Wang, Y. Xin, H. Cao, W. Li, Y. Hua, T.J. Webster, C. Zhang, W. Tang, Z. Liu, Recent advances in mesenchymal stem cell membrane-coated nanoparticles for enhanced drug delivery, Biomater. Sci. 9 (2021) 1088-1103. Copyright 2021 Royal Society of Chemistry.
Fig. 4
Fig. 4
Preparation and characterization of MSC membrane-coated DOX-MSN (DOX-MSN@M) as biomimetic vehicles for effective anti-tumor therapy [52]. Adapted from Li et al. (2021). Reprinted from J Control Release, 335, Y.S. Li, H.H. Wu, X.C. Jiang, T.Y. Zhang, Y. Zhou, L.L. Huang, P. Zhi, Y. Tabata, J.Q. Gao, Active stealth and self-positioning biomimetic vehicles achieved effective antitumor therapy, Pages 515-526, Copyright 2021, with permission from Elsevier.
Fig. 5
Fig. 5
The anti-tumor effects of SUCNPs@mSiO2 with PDT treatment were evaluated in vivo [56]. Adapted from Gao et al. (2016). Reprinted with permission from C. Gao, Z. Lin, Z. Wu, X. Lin, Q. He, Stem-cell-membrane camouflaging on near-infrared photoactivated upconversion nanoarchitectures for in vivo remote-controlled photodynamic therapy, ACS Appl. Mater. Interfaces 8 (2016) 34252-34260. Copyright 2016 American Chemical Society.
Fig. 6
Fig. 6
Schematic illustration of human iPS cells for targeted delivery of gold nanorods and enhanced photothermal therapy for tumors [74]. Adapted from Liu et al. (2016). Reprinted with permission from Y. Liu, M. Yang, J. Zhang, X. Zhi, C. Li, C. Zhang, F. Pan, K. Wang, Y. Yang, J. Martinez de la Fuentea, D. Cui, Human induced pluripotent stem cells for tumor targeted delivery of gold nanorods and enhanced photothermal therapy, ACS Nano 10 (2016) 2375-2385. Copyright 2016 American Chemical Society. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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