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Review
. 2022 Jul 9;14(7):e26699.
doi: 10.7759/cureus.26699. eCollection 2022 Jul.

Association of Serum Hepcidin With Preeclampsia: A Systematic Review and Meta-Analysis

Arkapal Bandyopadhyay  1 , Farhad Ahamed  2 , Sarika Palepu  2 , Tandra Ghosh  3 , Vikas Yadav  4
Affiliations
Review

Association of Serum Hepcidin With Preeclampsia: A Systematic Review and Meta-Analysis

Arkapal Bandyopadhyay et al. Cureus. .

Abstract

The objective of the present systematic review and meta-analysis was to compare the levels of serum hepcidin in women who developed pre-eclampsia with those who did not. The databases PubMed, Embase, Scopus, Cochrane, and references of retrieved articles published till September 2020 were searched with no language restriction. Mean differences in iron regulating protein (hepcidin) were compared using a random-effects model based on the level of heterogeneity. A total of 760 individuals were included in the analysis from seven studies. The pooled estimate showed that mean hepcidin levels were significantly higher in women who developed pre-eclampsia [0.3 ng/ml, 95% confidence interval (CI): 0.01-0.59, p=0.003] as compared to women who did not develop pre-eclampsia. Further research can be done to assess the levels of various iron parameters in different trimesters of pregnancy and their association with pre-eclampsia.

Keywords: ferritin; hepcidin; iron parameters; pre-eclampsia; pregnancy; transferrin.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. PRISMA flowchart of study selection process
Figure 2
Figure 2. Forest plot of studies estimating serum mean hepcidin levels
Sources: Toldi et al. [12], Duvan et al. [13], Muhsin et al. [14], Cardaropoli et al. [15], Brunacci et al. [16], Kumar et al. [17], Nila et al. [18]
Figure 3
Figure 3. Forest plot of studies estimating transferrin saturation percentage
Sources: Toldi et al. [12], Duvan et al. [13], Muhsin et al. [14], Brunacci et al. [16], Nila et al. [18]
Figure 4
Figure 4. Forest plot of studies estimating ferritin levels
Sources: Toldi et al. [12], Duvan et al. [13], Muhsin et al. [14], Brunacci et al. [16], Nila et al. [18]
Figure 5
Figure 5. Funnel plot of included studies
See this image and copyright information in PMC

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