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Review
. 2022 Jul;47(4):300-313.
doi: 10.30476/IJMS.2021.88511.1927.

Therapeutic Potential of Bee and Scorpion Venom Phospholipase A2 (PLA2): A Narrative Review

Parisa Soltan-Alinejad  1 , Hamzeh Alipour  1 , Davood Meharabani  2   3 , Kourosh Azizi  1
Affiliations
Review

Therapeutic Potential of Bee and Scorpion Venom Phospholipase A2 (PLA2): A Narrative Review

Parisa Soltan-Alinejad et al. Iran J Med Sci. 2022 Jul.

Abstract

Venomous arthropods such as scorpions and bees form one of the important groups with an essential role in medical entomology. Their venom possesses a mixture of diverse compounds, such as peptides, some of which have toxic effects, and enzymatic peptide Phospholipase A2 (PLA2) with a pharmacological potential in the treatment of a wide range of diseases. Bee and scorpion venom PLA2 group III has been used in immunotherapy, the treatment of neurodegenerative and inflammatory diseases. They were assessed for antinociceptive, wound healing, anti-cancer, anti-viral, anti-bacterial, anti-parasitic, and anti-angiogenesis effects. PLA2 has been identified in different species of scorpions and bees. The anti-leishmania, anti-bacterial, anti-viral, and anti-malarial activities of scorpion PLA2 still need further investigation. Many pieces of research have been stopped in the laboratory stage, and several studies need vast investigation in the clinical phase to show the pharmacological potential of PLA2. In this review, the medical significance of PLA2 from the venom of two arthropods, namely bees and scorpions, is discussed.

Keywords: Bees; Phospholipases A2; Scorpions; Venoms.

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References

    1. Jo M, Park MH, Kollipara PS, An BJ, Song HS, Han SB, et al. Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway. Toxicol Appl Pharmacol. 2012;258:72–81. doi: 10.1016/j.taap.2011.10.009. - DOI - PubMed
    1. Mamelak AN, Jacoby DB. Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601) Expert Opin Drug Deliv. 2007;4:175–86. doi: 10.1517/17425247.4.2.175. - DOI - PubMed
    1. Remijsen Q, Verdonck F, Willems J. Parabutoporin, a cationic amphipathic peptide from scorpion venom: much more than an antibiotic. Toxicon. 2010;55:180–5. doi: 10.1016/j.toxicon.2009.10.027. - DOI - PubMed
    1. Hider RC. Honeybee venom: a rich source of pharmacologically active peptides. Endeavour. 1988;12:60–5. doi: 10.1016/0160-9327(88)90082-8. - DOI - PubMed
    1. Najafian M, Ghorbani A, Zargar M, Baradaran M, Baradaran N. Scorpion stings in pregnancy: an analysis of outcomes in 66 envenomed pregnant patients in Iran. J Venom Anim Toxins Incl Trop Dis. 2020;26:e20190039. doi: 10.1590/1678-9199-JVATITD-2019-0039. [ PMC Free Article ] - DOI - PMC - PubMed

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