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Review
. 2022 Sep 29;11(9):408-412.
doi: 10.1093/jpids/piac045.

Human Astrovirus VA1 Encephalitis in Pediatric Patients With Cancer: Report of 2 Cases and Review of the Literature

Sakshi Bami  1 , Jennifer Hidinger  2 , Arshia Madni  1   3 , Virginia Hargest  2 , Stacey Schultz-Cherry  2 , Valerie Cortez  4 , Shane J Cross  5 , Deborah A Ward  5 , Randall T Hayden  6 , Jeffrey Rubnitz  7 , Ching-Hon Pui  6   7 , Raja B Khan  8 , Diego R Hijano  2
Affiliations
Review

Human Astrovirus VA1 Encephalitis in Pediatric Patients With Cancer: Report of 2 Cases and Review of the Literature

Sakshi Bami et al. J Pediatric Infect Dis Soc. .

Abstract

Novel human astroviruses (HAstVs) have recently been implicated as rare causes of fatal encephalitis in immunocompromised patients, for which there is no proven treatment. We report 2 cases from our institution in which HAstV-VA1 was detected in the cerebrospinal fluid by metagenomic next-generation sequencing after the initial evaluation revealed no etiology.

Keywords: VA1; astrovirus; cancer; children; encephalitis.

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