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Comparative Study
. 1978 Aug;75(8):3732-6.
doi: 10.1073/pnas.75.8.3732.

Partial amino acid sequence of penicillinase coded by Escherichia coli plasmid R6K

R P Ambler, G K Scott
Comparative Study

Partial amino acid sequence of penicillinase coded by Escherichia coli plasmid R6K

R P Ambler et al. Proc Natl Acad Sci U S A. 1978 Aug.

Abstract

Direct studies of the amino acid sequence of an Escherichia coli plasmid-coded penicillinase (penicillin amido-beta-lactamhydrolase, EC 3.5.2.6) are in complete agreement with results derived from the translation of the DNA sequence of a related plasmid, apart from a single amino acid substitution. This penicillinase from a Gram-negative bacterium shows 30-35% identity with functionally similar enzymes from Gram-positive bacteria. This paper should be read in conjunction with the report of the DNA sequence of the gene.

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References

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