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Review
. 2022 Jun 13:3:100113.
doi: 10.1016/j.crphar.2022.100113. eCollection 2022.

Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders

Milind V Masule  1 , Sumit Rathod  2 , Yogeeta Agrawal  2 , Chandragouda R Patil  1 , Kartik T Nakhate  2 , Shreesh Ojha  3 , Sameer N Goyal  2 , Umesh B Mahajan  1
Affiliations
Review

Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders

Milind V Masule et al. Curr Res Pharmacol Drug Discov. .

Abstract

Ghrelin is a peptide released by the endocrine cells of the stomach and the neurons in the arcuate nucleus of the hypothalamus. It modulates both peripheral and central functions. Although ghrelin has emerged as a potent stimulator of growth hormone release and as an orexigenic neuropeptide, the wealth of literature suggests its involvement in the pathophysiology of affective disorders including depression. Ghrelin exhibits a dual role through the advancement and reduction of depressive behavior with nervousness in the experimental animals. It modulates depression-related signals by forming neuronal networks with various neuropeptides and classical neurotransmitter systems. The present review emphasizes the integration and signaling of ghrelin with other neuromodulatory systems concerning depressive disorders. The role of ghrelin in the regulation of neurosynaptic transmission and depressive illnesses implies that the ghrelin system modulation can yield promising antidepressive therapies.

Keywords: Depression; GHSR; Ghrelin; Neurotransmitter; Psychotic disorders.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Biological functions of ghrelin on different body systems.
Fig. 2
Fig. 2
Ghrelin signling in depression.
Fig. 3
Fig. 3
Involvement of ghrelin in different signaling pathways and its physiological roles in impacting the different situations.
Fig. 4
Fig. 4
Ghrelin release and actions.
See this image and copyright information in PMC

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