Gene-Based Natural Killer Cell Therapies for the Treatment of Pediatric Hematologic Malignancies
- PMID: 35773048
- PMCID: PMC10158845
- DOI: 10.1016/j.hoc.2022.03.007
Gene-Based Natural Killer Cell Therapies for the Treatment of Pediatric Hematologic Malignancies
Abstract
Pediatric blood cancers are among the most common malignancies that afflict children. Intensive chemotherapy is not curative in many cases, and novel therapies are urgently needed. NK cells hold promise for use as immunotherapeutic effectors due to their favorable safety profile, intrinsic cytotoxic properties, and potential for genetic modification that can enhance specificity and killing potential. NK cells can be engineered to express CARs targeting tumor-specific antigens, to downregulate inhibitory and regulatory signals, to secrete cytokine, and to optimize interaction with small molecule engagers. Understanding NK cell biology is key to designing immunotherapy for clinical translation.
Keywords: Blood cancer; Genetic engineering; Immunotherapy; NK cell.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Disclosure C.L. Bonifant and I. Christodoulou have pending patent applications describing the use of CAR-NK cells as therapeutics. C.L. Bonifant and I. Christodoulou have received research support from Merck Sharp and Dohme, Bristol-Myers Squibb, and Kiadis Pharma.
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