Cancer Stem Cells and Chemoresistance in Ewing Sarcoma
- PMID: 35761483
- DOI: 10.2174/1574888X17666220627114710
Cancer Stem Cells and Chemoresistance in Ewing Sarcoma
Abstract
Resistance to chemotherapy poses a major challenge for cancer treatment. Reactivating a stem cell program resembling that seen in embryonic development can lead cancer cells to acquire a stem-cell phenotype characterized by expression of stemness genes, pluripotency, high self-renewal ability, and tumor-initiating capability. These cancer stem cells (CSCs) are usually resistant to anticancer drugs and are likely involved in treatment failure in many cancer types. Ewing sarcoma (ES) is a pediatric cancer type typically resulting from a typical genetic alteration affecting bone or soft tissues. Despite advances in treatment, survival prognostic remains poor for patients with refractory or recurrent disease. Here, we review the increasing evidence indicating that ES tumors contain a CSC subpopulation expressing stem cell genes, including BM1, OCT3/4, NANOG, and SOX2, that plays a role in resistance to drug treatment, and current experimental strategies that successfully counteract chemoresistance mediated by CSCs in ES.
Keywords: Ewing sarcoma; cancer stem cell; chemoresistance; pediatric cancer; sarcoma; stem cell.
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Similar articles
-
RNA sequencing and functional studies of patient-derived cells reveal that neurexin-1 and regulators of this pathway are associated with poor outcomes in Ewing sarcoma.Cell Oncol (Dordr). 2021 Oct;44(5):1065-1085. doi: 10.1007/s13402-021-00619-8. Epub 2021 Aug 17. Cell Oncol (Dordr). 2021. PMID: 34403115 Free PMC article.
-
C/EBPβ-1 promotes transformation and chemoresistance in Ewing sarcoma cells.Oncotarget. 2017 Apr 18;8(16):26013-26026. doi: 10.18632/oncotarget.14847. Oncotarget. 2017. PMID: 28148901 Free PMC article.
-
EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistance.Mol Cancer Res. 2012 Aug;10(8):1098-108. doi: 10.1158/1541-7786.MCR-12-0086. Epub 2012 Jun 20. Mol Cancer Res. 2012. PMID: 22723308 Free PMC article.
-
Ewing's sarcoma cancer stem cell targeted therapy.Curr Stem Cell Res Ther. 2014 Jan;9(1):46-62. doi: 10.2174/1574888x08666131203123125. Curr Stem Cell Res Ther. 2014. PMID: 24294922 Review.
-
Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells.Int J Mol Sci. 2017 Aug 24;18(9):1849. doi: 10.3390/ijms18091849. Int J Mol Sci. 2017. PMID: 28837080 Free PMC article. Review.
Cited by
-
Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma.Cancers (Basel). 2023 Oct 10;15(20):4911. doi: 10.3390/cancers15204911. Cancers (Basel). 2023. PMID: 37894278 Free PMC article.
-
Unlocking epigenetics for precision treatment of Ewing's sarcoma.Chin J Cancer Res. 2024 Jun 30;36(3):322-340. doi: 10.21147/j.issn.1000-9604.2024.03.08. Chin J Cancer Res. 2024. PMID: 38988487 Free PMC article.
-
Stemness and Cell Cycle Regulators and Their Modulation by Retinoic Acid in Ewing Sarcoma.Curr Issues Mol Biol. 2024 Apr 26;46(5):3990-4003. doi: 10.3390/cimb46050246. Curr Issues Mol Biol. 2024. PMID: 38785514 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
