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Randomized Controlled Trial
. 2022 Jun 9;14(12):2393.
doi: 10.3390/nu14122393.

Improving Dietary Intake of Essential Nutrients Can Ameliorate Inflammation in Patients with Diabetic Foot Ulcers

Raedeh Basiri  1   2   3 , Maria Spicer  2 , Cathy Levenson  4 , Thomas Ledermann  5 , Neda Akhavan  2   3 , Bahram Arjmandi  2   3
Affiliations
Randomized Controlled Trial

Improving Dietary Intake of Essential Nutrients Can Ameliorate Inflammation in Patients with Diabetic Foot Ulcers

Raedeh Basiri et al. Nutrients. .

Abstract

Diabetic foot ulcers (DFUs) are classified as chronic wounds and are one of the most common complications of diabetes. In chronic wounds, management of inflammation is a key step in treatment. Nutrition plays an important role in managing and controlling inflammation. This study evaluated the effects of nutrition supplementation and education on inflammatory biomarkers in patients with DFUs. Eligible patients with foot ulcers were randomly assigned to either a treatment (n = 15) or control group (n = 14). Both groups received standard care for wound treatment from the clinic; however, the treatment group was also provided with nutritional supplementation and education. Plasma concentrations of inflammatory biomarkers, namely C-reactive protein (CRP), interleukin 6 (IL6), interleukin 10 (IL10), and tristetraprolin (TTP), were evaluated at baseline and every four weeks, until complete wound closure had occurred or up to 12 weeks. The mean plasma concentration of IL6 significantly decreased in the treatment group (p = 0.001). The interaction between time and group was not statistically significant for the mean plasma concentrations of CRP, IL10, and TTP during the 12 weeks of the study. The results of this study showed the positive effects of nutritional intervention on controlling inflammation in DFU patients. More clinical trials with a larger population and longer duration of time are needed to confirm our results.

Keywords: CRP; IL10; IL6; TTP; anti-inflammatory cytokines; chronic wounds; cytokines; diabetes; diabetic foot ulcer; inflammation; nutrient supplementation; nutrition education; nutrition intervention; pro-inflammatory cytokines; tristetraprolin; wound healing.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Comparison of mean plasma concentrations of IL6 (pg/mL) between the treatment and control group during the 12 weeks of the study. Bars represent the means ± SEM. * Denotes a significant time by group interaction (p < 0.05).
Figure 2
Figure 2
Comparison of mean plasma concentrations of TTP (pg/mL) between the treatment and control group during the 12 weeks of the study. Bars represent the means ± SEM.
See this image and copyright information in PMC

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