Current state and future opportunities in granulocyte colony-stimulating factor (G-CSF)

doi:10.1007/s00520-022-07103-5

Editorial

. 2022 Sep;30(9):7067-7077.

doi: 10.1007/s00520-022-07103-5.

Current state and future opportunities in granulocyte colony-stimulating factor (G-CSF)

Hartmut Link¹

Affiliations

PMID: 35739328
PMCID: PMC9225876
DOI: 10.1007/s00520-022-07103-5

Editorial

Current state and future opportunities in granulocyte colony-stimulating factor (G-CSF)

Hartmut Link. Support Care Cancer. 2022 Sep.

. 2022 Sep;30(9):7067-7077.

doi: 10.1007/s00520-022-07103-5.

Author

Hartmut Link¹

Affiliation

¹ , Kaiserslautern, Germany. hlink@kabelmail.de.

PMID: 35739328
PMCID: PMC9225876
DOI: 10.1007/s00520-022-07103-5

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Figures

**Fig. 1**
Synopsis of international guidelines on the prophylactic use of G-CSF; additional risk factors mentioned by ASCO guidelines: advanced disease, poor performance status or poor nutritional status, cardiovascular disease multiple comorbid conditions HIV infection [23]. Secondary prophylaxis is indicated if neutropenia complications occurred without G-CSF or neutropenia-related cycle delays were necessary. Assessment is required after each cycle of chemotherapy.

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References

1. Welte K, Platzer E, Lu L, Gabrilove JL, Levi E, Mertelsmann R, et al. Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor. Proc Natl Acad Sci. 1985;82(5):1526–1530. doi: 10.1073/pnas.82.5.1526. - DOI - PMC - PubMed
1. Welte K, Gabrilove J, Bronchud MH, Platzer E, Morstyn G. Filgrastim (r-metHuG-CSF): The first 10 years. Blood. 1996;88(6):1907–1929. doi: 10.1182/blood.V88.6.1907.bloodjournal8861907. - DOI - PubMed
1. Metcalf D. The colony-stimulating factors and cancer. Cancer Immunol Res. 2013;1(6):351–356. doi: 10.1158/2326-6066.cir-13-0151. - DOI - PMC - PubMed
1. Souza LM, Boone TC, Gabrilove J, Lai PH, Zsebo KM, Murdock DC, et al. Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells. Science. 1986;232(4746):61–65. doi: 10.1126/science.2420009. - DOI - PubMed
1. Demetri GD, Griffin JD. Granulocyte colony-stimulating factor and its receptor. Blood. 1991;78(11):2791–2808. doi: 10.1182/blood.v78.11.2791.2791. - DOI - PubMed

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[1] Welte K, Platzer E, Lu L, Gabrilove JL, Levi E, Mertelsmann R, et al. Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor. Proc Natl Acad Sci. 1985;82(5):1526–1530. doi: 10.1073/pnas.82.5.1526. - DOI - PMC - PubMed

[2] Welte K, Platzer E, Lu L, Gabrilove JL, Levi E, Mertelsmann R, et al. Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor. Proc Natl Acad Sci. 1985;82(5):1526–1530. doi: 10.1073/pnas.82.5.1526. - DOI - PMC - PubMed

[3] Welte K, Gabrilove J, Bronchud MH, Platzer E, Morstyn G. Filgrastim (r-metHuG-CSF): The first 10 years. Blood. 1996;88(6):1907–1929. doi: 10.1182/blood.V88.6.1907.bloodjournal8861907. - DOI - PubMed

[4] Welte K, Gabrilove J, Bronchud MH, Platzer E, Morstyn G. Filgrastim (r-metHuG-CSF): The first 10 years. Blood. 1996;88(6):1907–1929. doi: 10.1182/blood.V88.6.1907.bloodjournal8861907. - DOI - PubMed

[5] Metcalf D. The colony-stimulating factors and cancer. Cancer Immunol Res. 2013;1(6):351–356. doi: 10.1158/2326-6066.cir-13-0151. - DOI - PMC - PubMed

[6] Metcalf D. The colony-stimulating factors and cancer. Cancer Immunol Res. 2013;1(6):351–356. doi: 10.1158/2326-6066.cir-13-0151. - DOI - PMC - PubMed

[7] Souza LM, Boone TC, Gabrilove J, Lai PH, Zsebo KM, Murdock DC, et al. Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells. Science. 1986;232(4746):61–65. doi: 10.1126/science.2420009. - DOI - PubMed

[8] Souza LM, Boone TC, Gabrilove J, Lai PH, Zsebo KM, Murdock DC, et al. Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells. Science. 1986;232(4746):61–65. doi: 10.1126/science.2420009. - DOI - PubMed

[9] Demetri GD, Griffin JD. Granulocyte colony-stimulating factor and its receptor. Blood. 1991;78(11):2791–2808. doi: 10.1182/blood.v78.11.2791.2791. - DOI - PubMed

[10] Demetri GD, Griffin JD. Granulocyte colony-stimulating factor and its receptor. Blood. 1991;78(11):2791–2808. doi: 10.1182/blood.v78.11.2791.2791. - DOI - PubMed

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Current state and future opportunities in granulocyte colony-stimulating factor (G-CSF)

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Current state and future opportunities in granulocyte colony-stimulating factor (G-CSF)

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