Modeling undetected live type 1 wild poliovirus circulation after apparent interruption of transmission: Pakistan and Afghanistan
- PMID: 35739067
- PMCID: PMC9780400
- DOI: 10.1111/risa.13982
Modeling undetected live type 1 wild poliovirus circulation after apparent interruption of transmission: Pakistan and Afghanistan
Abstract
Since 2013, wild poliovirus (WPV) transmission occurred only for type 1 (WPV1). Following several years of increasing reported incidence (2017-2019) and programmatic disruptions caused by COVID-19 (early 2020), Pakistan and Afghanistan performed a large number of supplementary immunization activities (late 2020-2021). This increased intensity of immunization, following widespread transmission, substantially decreased WPV1 cases and positive environmental samples during 2021. Modeling the potential for undetected circulation of WPV1 after apparent interruption can support regional and global decisions about certification of the eradication of indigenous WPV1 transmission. We apply a stochastic model to estimate the confidence about no circulation (CNC) of WPV1 in Pakistan and Afghanistan as a function of time since the last reported case and/or positive environmental sample. Exploration of different assumptions about surveillance quality suggests a range for CNC for WPV1 as a function of time since the last positive surveillance signal, and supports the potential use of a time with no evidence of transmission of less than 3 years as sufficient to assume die out in the context of good acute flaccid paralysis (AFP) surveillance. We show high expected CNC based on AFP surveillance data alone, even with imperfect surveillance and some use of inactivated poliovirus vaccine masking the ability of AFP surveillance to detect transmission. Ensuring high quality AFP and environmental surveillance may substantially shorten the time required to reach high CNC. The time required for high CNC depends on whether immunization activities maintain high population immunity and the quality of surveillance data.
Keywords: Afghanistan; Pakistan; eradication; infection transmission modeling; polio; vaccination.
© 2022 Society for Risk Analysis.
Figures
Similar articles
-
Modeling scenarios for ending poliovirus transmission in Pakistan and Afghanistan.Risk Anal. 2023 Apr;43(4):660-676. doi: 10.1111/risa.13983. Epub 2022 Jun 23. Risk Anal. 2023. PMID: 35739080 Free PMC article.
-
Modeling Undetected Live Poliovirus Circulation After Apparent Interruption of Transmission: Pakistan and Afghanistan.Risk Anal. 2019 Feb;39(2):402-413. doi: 10.1111/risa.13214. Epub 2018 Oct 8. Risk Anal. 2019. PMID: 30296340 Free PMC article.
-
Evaluation of Proactive and Reactive Strategies for Polio Eradication Activities in Pakistan and Afghanistan.Risk Anal. 2019 Feb;39(2):389-401. doi: 10.1111/risa.13194. Epub 2018 Sep 21. Risk Anal. 2019. PMID: 30239026 Free PMC article.
-
Insights From Modeling Preventive Supplemental Immunization Activities as a Strategy to Eliminate Wild Poliovirus Transmission in Pakistan and Afghanistan.Risk Anal. 2021 Feb;41(2):266-272. doi: 10.1111/risa.13471. Epub 2020 Mar 6. Risk Anal. 2021. PMID: 32144841 Free PMC article.
-
The immediate impact of the COVID-19 pandemic on polio immunization and surveillance activities.Vaccine. 2023 Apr 6;41 Suppl 1:A2-A11. doi: 10.1016/j.vaccine.2021.10.028. Epub 2021 Oct 22. Vaccine. 2023. PMID: 34756614 Free PMC article. Review.
Cited by
-
Review of Poliovirus Transmission and Economic Modeling to Support Global Polio Eradication: 2020-2024.Pathogens. 2024 May 22;13(6):435. doi: 10.3390/pathogens13060435. Pathogens. 2024. PMID: 38921733 Free PMC article. Review.
-
Modeling undetected poliovirus circulation following the 2022 outbreak in the United States.Expert Rev Vaccines. 2024 Jan-Dec;23(1):186-195. doi: 10.1080/14760584.2023.2299401. Epub 2024 Jan 4. Expert Rev Vaccines. 2024. PMID: 38164695 Free PMC article.
-
Immune persistence of an inactivated poliovirus vaccine derived from the Sabin strain: a 10-year follow-up of a phase 3 study.EClinicalMedicine. 2023 Sep 14;64:102151. doi: 10.1016/j.eclinm.2023.102151. eCollection 2023 Oct. EClinicalMedicine. 2023. PMID: 37745024 Free PMC article.
-
Coordinated global cessation of oral poliovirus vaccine use: Options and potential consequences.Risk Anal. 2024 Feb;44(2):366-378. doi: 10.1111/risa.14158. Epub 2023 Jun 21. Risk Anal. 2024. PMID: 37344934 Free PMC article. Review.
-
Modeling scenarios for ending poliovirus transmission in Pakistan and Afghanistan.Risk Anal. 2023 Apr;43(4):660-676. doi: 10.1111/risa.13983. Epub 2022 Jun 23. Risk Anal. 2023. PMID: 35739080 Free PMC article.
References
-
- Anis E, Kopel E, Singer S, Kaliner E, Moerman L, Moran-Gilad J, … Grotto I (2013). Insidious reintroduction of wild poliovirus into Israel, 2013. Euro Surveillance, 18(38), 20586. - PubMed
-
- Blomqvist S, El Bassioni L, El Maamoon Nasr EM, Paananen A, Kaijalainen S, Asghar H, … Roivainen M (2012). Detection of imported wild polioviruses and of vaccine-derived polioviruses by environmental surveillance in Egypt. Appl Environ Microbiol, 78(15), 5406–5409. doi:10.1128/aem.00491-12 - DOI - PMC - PubMed
-
- Duintjer Tebbens RJ, Pallansch MA, Cochi SL, Ehrhardt DT, Farag NH, Hadler SC, … Thompson KM (2018). Modeling poliovirus transmission in Pakistan and Afghanistan to inform vaccination strategies in undervaccinated subpopulations. Risk Anal, 38(8), 1701–1717. doi:10.1111/risa.12962 - DOI - PMC - PubMed
-
- Duintjer Tebbens RJ, & Thompson KM (2009). Priority shifting and the dynamics of managing eradicable infectious disease. Management Science, 55(4), 650–663.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical