Skip to main page content
U.S. flag

An official website of the United States government

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jun 6:13:865777.
doi: 10.3389/fimmu.2022.865777. eCollection 2022.

Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease

Reza Yarani  1   2 , Ali Shojaeian  3 , Oana Palasca  4   5   6 , Nadezhda T Doncheva  4   5   6 , Lars Juhl Jensen  4   5 , Jan Gorodkin  5   6 , Flemming Pociot  1   5   7   8
Affiliations
Review

Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease

Reza Yarani et al. Front Immunol. .

Abstract

Differential microRNA (miRNA or miR) regulation is linked to the development and progress of many diseases, including inflammatory bowel disease (IBD). It is well-established that miRNAs are involved in the differentiation, maturation, and functional control of immune cells. miRNAs modulate inflammatory cascades and affect the extracellular matrix, tight junctions, cellular hemostasis, and microbiota. This review summarizes current knowledge of differentially expressed miRNAs in mucosal tissues and peripheral blood of patients with ulcerative colitis and Crohn's disease. We combined comprehensive literature curation with computational meta-analysis of publicly available high-throughput datasets to obtain a consensus set of miRNAs consistently differentially expressed in mucosal tissues. We further describe the role of the most relevant differentially expressed miRNAs in IBD, extract their potential targets involved in IBD, and highlight their diagnostic and therapeutic potential for future investigations.

Keywords: Crohn’s disease; Transcriptomics; inflammatory bowel disase; miRNA; ulcerative colitis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Dot-plot of the 29 differentially expressed miRNAs (at least two studies) in either colon or blood of UC or CD from literature. The node size represents the number of studies, and the node color corresponds to the expression statues, where red means upregulation and blue means downregulation.
Figure 2
Figure 2
Network representations of the 28 miRNAs with at least one experimentally determined target known to be related to IBD. (A) Network of miRNAs only. Dark gray nodes represent miRNAs detected by literature curation, while light gray nodes were not identified in the literature, but only in the meta-analysis. The size of each miRNA node corresponds to the number of IBD targets this miRNA has, and the width of the edges represents the number of shared IBD targets. The mean logFC of each miRNA, according to the meta-analysis, is shown for CD (left) and UC (right) using a blue-white-red gradient on the node border. (B) Network of miRNAs (oval nodes) and their target genes (rectangle nodes). miRNAs are colored based on their mean expression rank. Target genes that code for proteins with a clinically approved drug according to the Pharos database are highlighted by dark gray node border color.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Kalla R, Ventham NT, Satsangi J, Arnott IDR. Crohn’s Disease. BMJ (2014) 349:g6670. doi: 10.1136/bmj.g6670 - DOI - PubMed
    1. Ford AC, Moayyedi P, Hanauer SB. Ulcerative Colitis. BMJ (2013) 346(feb05 2):f432–f. doi: 10.1136/bmj.f432 - DOI - PubMed
    1. Wang H, Zhang S, Yu Q, Yang G, Guo J, Li M, et al. . Circulating MicroRNA223 Is a New Biomarker for Inflammatory Bowel Disease. Medicine (2016) 95(5):e2703. doi: 10.1097/MD.0000000000002703 - DOI - PMC - PubMed
    1. Baumgart DC, Sandborn WJ. Crohn’s Disease. Lancet (2012) 380(9853):1590–605. doi: 10.1016/S0140-6736(12)60026-9 - DOI - PubMed
    1. Kappelman MD, Rifas-Shiman SL, Kleinman K, Ollendorf D, Bousvaros A, Grand RJ, et al. . The Prevalence and Geographic Distribution of Crohn’s Disease and Ulcerative Colitis in the United States. Clin Gastroenterol Hepatol (2007) 5(12):1424–9. doi: 10.1016/j.cgh.2007.07.012 - DOI - PubMed