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. 2022 Jun 7;119(23):e2205124119.
doi: 10.1073/pnas.2205124119. Epub 2022 Jun 3.

The long and short of rDNA and yeast replicative aging

Jeffrey S Smith  1
Affiliations

The long and short of rDNA and yeast replicative aging

Jeffrey S Smith. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no competing interest.

Figures

Fig. 1.
Fig. 1.
S. cerevisiae RLS is dictated by the length of the rDNA tandem array located on chromosome XII. As the array becomes shorter, more ERCs accumulate in the aging mother cells, contributing to their senescence. ERCs can reintegrate into the short array while it is destabilized in order to expand again, a process regulated by Sir2 and the RNA polymerase I transcription factor, UAF. Created with BioRender.
See this image and copyright information in PMC

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  • doi: 10.1073/pnas.2119593119

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