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Review
. 2022 May 23:2022:6807700.
doi: 10.1155/2022/6807700. eCollection 2022.

Plants with Therapeutic Potential for Ischemic Acute Kidney Injury: A Systematic Review

Arif Ali  1 , Tiago Lima Sampaio  2 , Haroon Khan  3 , Philippe Jeandet  4 , Esra Küpeli Akkol  5 , Humaira Bahadar  6 , Alice Maria Costa Martins  2
Affiliations
Review

Plants with Therapeutic Potential for Ischemic Acute Kidney Injury: A Systematic Review

Arif Ali et al. Evid Based Complement Alternat Med. .

Abstract

Acute kidney injury (AKI) is a complex condition which has an intricate pathology mostly involving hemodynamic, inflammatory, and direct toxic effects at the cellular level with high morbidity and mortality ratios. Renal ischemic reperfusion injury (RIRI) is the main factor responsible for AKI, most often observed in different types of shock, kidney transplantation, sepsis, and postoperative procedures. The RIRI-induced AKI is accompanied by increased reactive oxygen species generation together with the activation of various inflammatory pathways. In this context, plant-derived medicines have shown encouraging nephroprotective properties. Evidence provided in this systemic review leads to the conclusion that plant-derived extracts and compounds exhibit nephroprotective action against renal ischemic reperfusion induced-AKI by increasing endogenous antioxidants and decreasing anti-inflammatory cytokines. However, there is no defined biomarker or target which can be used for treating AKI completely. These plant-derived extracts and compounds are only tested in selected transgenic animal models. To develop the results obtained into a therapeutic entity, one should apply them in proper vertebrate multitransgenic animal models prior to further validation in humans.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Effect of renal ischemic reperfusion (I/R) induced acute kidney injury (AKI) and administration of plant-derived extracts and compounds on kidney. The upward arrow shows “increase,” and downward arrow direction shows “decrease.”
See this image and copyright information in PMC

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